# OnCo record swog-s1406 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/swog-s1406/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "swog-s1406", "NCT02164916" ;
  schema:name "SWOG S1406"@en ;
  schema:description "The trial that explained why BRAF drugs alone fail in bowel cancer: blocking BRAF wakes up EGFR, so both must be blocked at once."@en ;
  schema:url <https://onco.cc/trials/swog-s1406/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02164916>, <https://doi.org/10.1200/JCO.20.01994> ;
  onco:status "positive" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/braf-v600e-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/braf/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/vemurafenib/>, <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/irinotecan/> ;
  onco:companies <https://onco.cc/companies/swog/> ;
  onco:trials <https://onco.cc/trials/beacon-crc/>, <https://onco.cc/trials/breakwater/> .