# OnCo record synthetic-lethality-map (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/synthetic-lethality-map/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "synthetic-lethality-map" ;
  schema:name "Synthetic lethality: paired dependencies"@en ;
  schema:description "Two genes are synthetically lethal when losing either alone is fine but losing both kills the cell. Cancers that have already lost one (a tumour suppressor you cannot put back) become uniquely dependent on the other, which you can drug. BRCA and PARP was the first proof; a dozen more pairs are now in trials."@en ;
  schema:url <https://onco.cc/pathways/synthetic-lethality-map/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Synthetic_lethality> ;
  schema:citation <https://doi.org/10.1126/science.aam7344>, <https://depmap.org/portal/> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/hrd-testing/>, <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/functional-drug-testing/> ;
  onco:targets <https://onco.cc/targets/parp/>, <https://onco.cc/targets/brca/>, <https://onco.cc/targets/wee1/>, <https://onco.cc/targets/atr/>, <https://onco.cc/targets/wrn/>, <https://onco.cc/targets/prmt5-mtap/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/hif2a/>, <https://onco.cc/targets/ezh2/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/niraparib/>, <https://onco.cc/drugs/talazoparib/>, <https://onco.cc/drugs/belzutifan/> ;
  onco:pathways <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/homologous-recombination-repair/>, <https://onco.cc/pathways/mismatch-repair-msi/>, <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/p53-mdm2-axis/>, <https://onco.cc/pathways/hif-vhl/> ;
  onco:terms <https://onco.cc/terms/synthetic-lethality/>, <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/msi/>, <https://onco.cc/terms/oncogene-addiction/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-lord-science/> .