# OnCo record t-cell-exhaustion-term (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/t-cell-exhaustion-term/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "t-cell-exhaustion-term" ;
  schema:name "T-cell exhaustion and CAR-T persistence"@en ;
  schema:alternateName "exhaustion"@en, "exhausted T cells"@en, "T-cell fitness"@en, "T cell fitness"@en, "T-cell dysfunction"@en, "CAR-T persistence"@en, "CAR persistence"@en, "CAR-T expansion"@en, "peak expansion"@en, "in vivo expansion"@en, "B-cell aplasia"@en, "loss of persistence"@en, "memory phenotype"@en, "stem-like T cells"@en ;
  schema:description "Immune T cells that have been fighting too long become 'exhausted': sluggish, covered in inhibitory receptors, unable to kill. It limits both the patient's natural anti-tumour response and how long engineered CAR-T cells keep working (persistence)."@en ;
  schema:url <https://onco.cc/terms/t-cell-exhaustion-term/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/T_cell_exhaustion> ;
  schema:citation <https://en.wikipedia.org/wiki/T_cell_exhaustion> ;
  onco:related <https://onco.cc/terms/antigen-escape/>, <https://onco.cc/terms/cold-vs-hot/>, <https://onco.cc/terms/hypogammaglobulinaemia/> ;
  onco:sections <https://onco.cc/fronts/cell-therapy/>, <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/armored-car/>, <https://onco.cc/technologies/checkpoint-inhibitor/> .