# OnCo record t-large-granular-lymphocytic-leukaemia (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/t-large-granular-lymphocytic-leukaemia/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "t-large-granular-lymphocytic-leukaemia" ;
  schema:name "T-cell large granular lymphocytic leukaemia"@en ;
  schema:alternateName "Large granular lymphocytic leukemia"@en, "Large granular lymphocytic leukaemia"@en, "LGL leukaemia"@en, "T-LGL leukaemia"@en, "T-LGLL"@en, "Chronic lymphoproliferative disorder of NK cells (related NK-cell form)"@en ;
  schema:description "T-cell large granular lymphocytic leukaemia is a slow, usually non-fatal leukaemia in which a clone of cytotoxic T cells builds up in the blood and marrow and turns the immune system against the body, causing low neutrophil counts, anaemia and often rheumatoid arthritis. It is treated only when it causes problems, with low-dose immune-suppressing drugs rather than chemotherapy."@en ;
  schema:url <https://onco.cc/cancers/t-large-granular-lymphocytic-leukaemia/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Large_granular_lymphocytic_leukemia> ;
  schema:citation <https://www.cancer.gov/types/leukemia/patient/cll-treatment-pdq>, <https://doi.org/10.1038/s41375-022-01620-2>, <https://doi.org/10.1056/nejmoa1114885>, <https://doi.org/10.1080/10428194.2017.1339880> ;
  onco:tag "subtype-page", "wave4", "haematologic", "rare" ;
  onco:related <https://onco.cc/cancers/leukaemia/>, <https://onco.cc/cancers/t-cell-prolymphocytic-leukaemia/>, <https://onco.cc/cancers/hepatosplenic-t-cell-lymphoma/>, <https://onco.cc/cancers/cll/> ;
  onco:targets <https://onco.cc/targets/stat3/> ;
  onco:drugs <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/cyclophosphamide/>, <https://onco.cc/drugs/alemtuzumab/>, <https://onco.cc/drugs/ruxolitinib/> ;
  onco:pathways <https://onco.cc/pathways/jak-stat/> ;
  onco:trials <https://onco.cc/trials/nct06224257/>, <https://onco.cc/trials/nct05475925/> ;
  onco:standardOfCare <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/cyclophosphamide/>, <https://onco.cc/drugs/alemtuzumab/>, <https://onco.cc/drugs/ruxolitinib/>, <https://onco.cc/cancers/leukaemia/> .