# OnCo record targeted-before-io-nsclc (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/targeted-before-io-nsclc/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "targeted-before-io-nsclc" ;
  schema:name "Sequence: targeted therapy before immunotherapy in driver-positive NSCLC"@en ;
  schema:description "If a lung cancer has a targetable mutation, give the pill first; immunotherapy works poorly in these tumours and raises the risk of severe side effects when a pill follows."@en ;
  schema:url <https://onco.cc/pairings/targeted-before-io-nsclc/> ;
  schema:dateModified "2026-09-06"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04194944>, <https://clinicaltrials.gov/study/NCT03052608> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/alk/>, <https://onco.cc/targets/ret/>, <https://onco.cc/targets/ros1/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/lorlatinib/>, <https://onco.cc/drugs/selpercatinib/>, <https://onco.cc/drugs/pembrolizumab/> ;
  onco:trials <https://onco.cc/trials/libretto-431/>, <https://onco.cc/trials/crown/>, <https://onco.cc/trials/mariposa/> ;
  onco:pairs <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/checkpoint-inhibitor/> .