# OnCo record tdo2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tdo2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tdo2" ;
  schema:name "TDO2"@en ;
  schema:alternateName "tryptophan 2,3-dioxygenase"@en, "TDO"@en, "TDO2" ;
  schema:description "TDO2 does the same job as IDO1, breaking down tryptophan into kynurenine, which quietens T cells. It is one reason IDO1 inhibitors alone may not have been enough; no TDO2 drug has reached late trials."@en ;
  schema:url <https://onco.cc/targets/tdo2/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11708>, <https://www.uniprot.org/uniprotkb/P48775/entry>, <https://www.ncbi.nlm.nih.gov/gene/6999>, <https://europepmc.org/article/MED/29254698> ;
  onco:tag "checkpoint-map" ;
  onco:targetClass "enzyme" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11708>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000151790>, <https://www.uniprot.org/uniprotkb/P48775/entry>, <https://www.ncbi.nlm.nih.gov/gene/6999> ;
  onco:related <https://onco.cc/targets/ido1/>, <https://onco.cc/drugs/epacadostat/> ;
  onco:pathways <https://onco.cc/pathways/cancer-immunity-cycle/> .