# OnCo record telomere-maintenance (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/telomere-maintenance/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "telomere-maintenance" ;
  schema:name "Telomere maintenance & replicative immortality"@en ;
  schema:description "Normal cells can divide only a limited number of times because the protective caps on their chromosomes, telomeres, wear down. About 90% of cancers switch the cap-rebuilding enzyme telomerase back on, often through TERT promoter mutations, and roughly 10% use an alternative lengthening route (ALT), so they divide indefinitely; imetelstat is the first approved telomerase inhibitor."@en ;
  schema:url <https://onco.cc/pathways/telomere-maintenance/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Telomerase> ;
  owl:sameAs <http://www.wikidata.org/entity/Q331839> ;
  schema:citation <https://doi.org/10.1038/s41576-019-0099-1> ;
  onco:tag "mechanism" ;
  onco:targets <https://onco.cc/targets/atr/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/>, <https://onco.cc/institutions/dana-farber/>, <https://onco.cc/institutions/ucsf/> ;
  onco:pathways <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/senescence/> ;
  onco:terms <https://onco.cc/terms/tert-promoter/>, <https://onco.cc/terms/enabling-replicative-immortality/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-shay-nat-rev-genet/> .