# OnCo record temozolomide (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/temozolomide/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "temozolomide" ;
  schema:name "Temozolomide"@en ;
  schema:description "The only chemotherapy proven to extend life in glioblastoma, given during and after radiation. It works best when the tumour has switched off a repair gene called MGMT."@en ;
  schema:url <https://onco.cc/drugs/temozolomide/> ;
  schema:dateModified "2026-09-06"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Temozolomide> ;
  owl:sameAs <http://www.wikidata.org/entity/Q425088> ;
  schema:citation <https://en.wikipedia.org/wiki/Temozolomide> ;
  onco:status "standard-of-care" ;
  onco:modality "Oral alkylating chemotherapy" ;
  schema:alternateName "Temodar" ;
  onco:approval "US 1999: Refractory anaplastic astrocytoma", "US 2005: Newly diagnosed glioblastoma with radiotherapy", "EU 1999: Temodal; malignant glioma (recurrent 1999; newly diagnosed glioblastoma with radiotherapy 2005); 26 Jan 1999" ;
  onco:acceleratedApproval "US 1999-08-11: Adults with refractory anaplastic astrocytoma" ;
  onco:acceleratedApprovalConfirmed "US 2005-03-15: Adults with refractory anaplastic astrocytoma" ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/idh-mutant-astrocytoma/>, <https://onco.cc/cancers/paediatric-high-grade-glioma/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/imrt-igrt/> ;
  onco:companies <https://onco.cc/companies/merck/> ;
  onco:terms <https://onco.cc/terms/mgmt/> ;
  onco:trials <https://onco.cc/trials/eortc-26981/>, <https://onco.cc/trials/catnon/>, <https://onco.cc/trials/eortc-22033/>, <https://onco.cc/trials/nct06703398/>, <https://onco.cc/trials/nct03709680/>, <https://onco.cc/trials/nct07326566/>, <https://onco.cc/trials/nct07310784/>, <https://onco.cc/trials/nct04478279/>, <https://onco.cc/trials/nct06595186/>, <https://onco.cc/trials/nct04752813/>, <https://onco.cc/trials/nct07569042/>, <https://onco.cc/trials/nct06703255/>, <https://onco.cc/trials/nct04485949/>, <https://onco.cc/trials/nct06413706/>, <https://onco.cc/trials/nct05765812/>, <https://onco.cc/trials/nct05440786/>, <https://onco.cc/trials/nct04587830/>, <https://onco.cc/trials/nct04121455/>, <https://onco.cc/trials/nct07297212/>, <https://onco.cc/trials/nct07492680/>, <https://onco.cc/trials/nct06012695/>, <https://onco.cc/trials/nct05902169/>, <https://onco.cc/trials/nct05417594/>, <https://onco.cc/trials/nct07015242/>, <https://onco.cc/trials/nct04443010/>, <https://onco.cc/trials/nct07195591/>, <https://onco.cc/trials/nct06556563/>, <https://onco.cc/trials/nct04910022/>, <https://onco.cc/trials/nct03491683/>, <https://onco.cc/trials/nct04919226/>, <https://onco.cc/trials/nct05768919/>, <https://onco.cc/trials/nct05664243/>, <https://onco.cc/trials/nct03862430/> .