# OnCo record tet2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tet2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tet2" ;
  schema:name "TET2"@en ;
  schema:alternateName "KIAA1546"@en, "tet methylcytosine dioxygenase 2"@en, "TET2" ;
  schema:description "TET2 is an enzyme that helps erase methyl marks from DNA so genes can be switched back on. Losing it is one of the commonest first steps toward blood cancer; mutant IDH blocks it indirectly, which is part of how ivosidenib works when it restores normal maturation."@en ;
  schema:url <https://onco.cc/targets/tet2/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25941>, <https://www.uniprot.org/uniprotkb/Q6N021/entry>, <https://www.ncbi.nlm.nih.gov/gene/54790> ;
  onco:tag "wave5-target" ;
  onco:targetClass "tumor-suppressor" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25941>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168769>, <https://www.uniprot.org/uniprotkb/Q6N021/entry>, <https://www.ncbi.nlm.nih.gov/gene/54790> ;
  onco:related <https://onco.cc/drugs/ivosidenib/>, <https://onco.cc/drugs/romidepsin/>, <https://onco.cc/targets/idh/>, <https://onco.cc/targets/dnmt3a/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/aml-idh/>, <https://onco.cc/cancers/peripheral-t-cell-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/epigenetic-drugs/> ;
  onco:pathways <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/clonal-haematopoiesis/>, <https://onco.cc/pathways/idh-2hg/> .