# OnCo record tgfbr1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tgfbr1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tgfbr1" ;
  schema:name "TGFBR1"@en ;
  schema:alternateName "transforming growth factor beta receptor 1"@en, "TGF-beta receptor type-1"@en, "ALK-5"@en, "ACVRLK4"@en, "ALK5"@en, "TBR-i"@en, "ESS1"@en, "TGFBR1" ;
  schema:description "TGFBR1 (TGF-beta receptor type-1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma."@en ;
  schema:url <https://onco.cc/targets/tgfbr1/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11772>, <https://www.uniprot.org/uniprotkb/P36897/entry>, <https://www.ncbi.nlm.nih.gov/gene/7046>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106799> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11772>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106799>, <https://www.uniprot.org/uniprotkb/P36897/entry>, <https://www.ncbi.nlm.nih.gov/gene/7046> ;
  onco:related <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/oesophageal-adenocarcinoma/> ;
  onco:pathways <https://onco.cc/pathways/tgf-beta/> .