# OnCo record tgfbr2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tgfbr2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tgfbr2" ;
  schema:name "TGFBR2"@en ;
  schema:alternateName "transforming growth factor beta receptor 2"@en, "TGF-beta receptor type-2"@en, "TBRII"@en, "TBR-ii"@en, "MFS2"@en, "TGFBR2" ;
  schema:description "TGFBR2 (TGF-beta receptor type-2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Oesophageal cancer, Pancreatic ductal adenocarcinoma and 5 more."@en ;
  schema:url <https://onco.cc/targets/tgfbr2/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11773>, <https://www.uniprot.org/uniprotkb/P37173/entry>, <https://www.ncbi.nlm.nih.gov/gene/7048>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163513> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11773>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163513>, <https://www.uniprot.org/uniprotkb/P37173/entry>, <https://www.ncbi.nlm.nih.gov/gene/7048> ;
  onco:related <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/cervical/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/rcc/> ;
  onco:pathways <https://onco.cc/pathways/tgf-beta/> .