# OnCo record theories-of-cancer (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/theories-of-cancer/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "theories-of-cancer" ;
  schema:name "Theories of cancer: how the ideas connect"@en ;
  schema:alternateName "theories of carcinogenesis"@en, "what is cancer"@en, "origin of cancer theories"@en, "cancer theory map"@en ;
  schema:description "Scientists have given more than a dozen answers to what cancer is: mutated genes, runaway evolution, misbehaving stem cells, disordered tissue, ancient cell programmes, broken chromosomes, metabolism, epigenetic switches, unhealed wounds, a failed immune system, ageing tissue, force or electricity. This map shows each theory, who proposed it, what held up, and how the ideas connect."@en ;
  schema:url <https://onco.cc/pathways/theories-of-cancer/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Carcinogenesis> ;
  schema:citation <https://doi.org/10.1016/j.semcancer.2008.03.012>, <https://doi.org/10.1158/2159-8290.CD-21-1059>, <https://doi.org/10.1038/nature10762>, <https://en.wikipedia.org/wiki/Carcinogenesis> ;
  onco:tag "mechanism", "mechanics-atlas", "theory" ;
  onco:related <https://onco.cc/terms/somatic-mutation-theory/>, <https://onco.cc/terms/driver-passenger-model/>, <https://onco.cc/terms/clonal-evolution-theory/>, <https://onco.cc/terms/hallmarks-synthesis/>, <https://onco.cc/terms/cancer-stem-cell-theory/>, <https://onco.cc/terms/epigenetic-progenitor-theory/>, <https://onco.cc/terms/aneuploidy-theory-of-cancer/>, <https://onco.cc/terms/metabolic-theory-of-cancer/>, <https://onco.cc/terms/tissue-organisation-field-theory/>, <https://onco.cc/terms/microenvironment-inflammation-theory/>, <https://onco.cc/terms/seed-and-soil-hypothesis/>, <https://onco.cc/terms/immune-surveillance-immunoediting/>, <https://onco.cc/terms/ageing-tissue-field-theory/>, <https://onco.cc/terms/atavistic-theory-of-cancer/>, <https://onco.cc/terms/mechanical-theory-of-cancer/>, <https://onco.cc/terms/bioelectric-theory-of-cancer/>, <https://onco.cc/terms/hallmarks-of-cancer/>, <https://onco.cc/technologies/mathematical-oncology/> ;
  onco:pathways <https://onco.cc/pathways/oncogene-activation-two-hit/>, <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/cancer-stem-cells-plasticity/>, <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/pathways/cancer-immunity-cycle/>, <https://onco.cc/pathways/organ-tropism-seed-soil/>, <https://onco.cc/pathways/clonal-haematopoiesis/>, <https://onco.cc/pathways/field-cancerisation/>, <https://onco.cc/pathways/caf-activation-desmoplasia/> ;
  onco:terms <https://onco.cc/terms/hallmarks-of-cancer/>, <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/warburg-effect/>, <https://onco.cc/terms/inflammation/>, <https://onco.cc/terms/metastasis/> ;
  onco:people <https://onco.cc/people/bert-vogelstein/>, <https://onco.cc/people/mel-greaves/>, <https://onco.cc/people/robert-gatenby/>, <https://onco.cc/people/robert-schreiber/>, <https://onco.cc/people/john-dick/>, <https://onco.cc/people/matthew-vander-heiden/>, <https://onco.cc/people/benjamin-ebert/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-hallmarks-of-cancer-cell-2000/>, <https://onco.cc/key-papers/paper-hallmarks-new-dimensions-cancer-discov-2022/>, <https://onco.cc/key-papers/paper-vogelstein-cancer-genome-landscapes-science-2013/>, <https://onco.cc/key-papers/paper-schreiber-cancer-immunoediting-science-2011/>, <https://onco.cc/key-papers/paper-greaves-nature/>, <https://onco.cc/key-papers/paper-sonnenschein-semin-cancer-biol/> .