# OnCo record therapeutic-index (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/therapeutic-index/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "therapeutic-index" ;
  schema:name "Therapeutic index (therapeutic window)"@en ;
  schema:alternateName "therapeutic window"@en, "therapeutic ratio"@en, "narrow therapeutic index"@en, "narrow therapeutic window"@en, "wide therapeutic window"@en, "safety margin"@en, "tolerability"@en, "tolerable"@en, "well tolerated"@en, "well-tolerated"@en, "toxicity profile"@en, "safety profile"@en, "on-target toxicity"@en, "off-target toxicity"@en, "on-target off-tumour"@en, "on-target, off-tumour"@en, "off-tumour"@en, "mechanism-based toxicity"@en, "class effect"@en, "class effects"@en, "toxicity profiles"@en ;
  schema:description "The gap between the dose that works and the dose that harms. Classic chemotherapy has a narrow window (the dose that kills the tumour nearly kills the patient); a wider window is the whole point of targeted drugs, ADCs and immunotherapy."@en ;
  schema:url <https://onco.cc/terms/therapeutic-index/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Therapeutic_index> ;
  schema:citation <https://en.wikipedia.org/wiki/Therapeutic_index> ;
  onco:related <https://onco.cc/terms/pharmacokinetics/>, <https://onco.cc/terms/mtd/>, <https://onco.cc/terms/dose-limiting-toxicity/>, <https://onco.cc/terms/ild/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/terms/project-optimus/>, <https://onco.cc/technologies/adc/> .