# OnCo record thiotepa (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/thiotepa/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "thiotepa" ;
  schema:name "Thiotepa"@en ;
  schema:alternateName "Thioplex (historic)"@en, "Triethylenethiophosphoramide"@en, "Tepadina" ;
  schema:description "Thiotepa is an old chemotherapy with a modern job: at high doses it prepares patients for stem cell transplants, and it is still instilled into the bladder or body cavities for superficial bladder cancer and malignant effusions."@en ;
  schema:url <https://onco.cc/drugs/thiotepa/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Thiotepa> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=thiotepa>, <https://www.cancer.gov/about-cancer/treatment/drugs/thiotepa>, <https://www.ema.europa.eu/en/medicines/human/EPAR/tepadina> ;
  onco:status "approved" ;
  onco:tag "nci-list" ;
  onco:modality "Alkylating agent (ethylenimine)" ;
  onco:approval "US 1959: Breast and ovarian adenocarcinoma; superficial papillary bladder carcinoma (intravesical); malignant effusions", "US 2017: Conditioning before allogeneic HSCT for class 3 beta-thalassaemia in children (Tepadina)", "EU 2010: Conditioning before haematopoietic progenitor cell transplantation for haematological diseases and solid tumours (Tepadina)" ;
  onco:cancers <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/primary-cns-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/allogeneic-hsct/>, <https://onco.cc/technologies/autologous-stem-cell-transplant/>, <https://onco.cc/technologies/bcg-and-intravesical-therapy/> ;
  onco:companies <https://onco.cc/companies/adienne/> .