# OnCo record tie2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tie2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tie2" ;
  schema:name "TIE2 receptor (TEK)"@en ;
  schema:description "TIE2 is the angiopoietin receptor that keeps blood vessels stable; regorafenib and cabozantinib block it as part of their attack on the tumour's blood supply."@en ;
  schema:url <https://onco.cc/targets/tie2/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/TEK_tyrosine_kinase>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11724>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120156>, <https://www.uniprot.org/uniprotkb/Q02763/entry>, <https://www.ncbi.nlm.nih.gov/gene/7010> ;
  schema:citation <https://www.uniprot.org/uniprotkb/Q02763/entry>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11724>, <https://www.ebi.ac.uk/chembl/explore/target/CHEMBL4128> ;
  schema:alternateName "TEK" ;
  onco:targetClass "kinase" ;
  onco:firstDescribed "1993"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/vegf/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/rcc/> ;
  onco:drugs <https://onco.cc/drugs/regorafenib/>, <https://onco.cc/drugs/cabozantinib/> ;
  onco:terms <https://onco.cc/terms/angiogenesis/> .