# OnCo record tigit-plus-pd1-caution (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/tigit-plus-pd1-caution/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "tigit-plus-pd1-caution" ;
  schema:name "Caution: TIGIT + PD-(L)1 blockade"@en ;
  schema:description "Adding a TIGIT blocker to PD-1/PD-L1 blockade looked good in phase 2 and then failed repeatedly in phase 3."@en ;
  schema:url <https://onco.cc/pairings/tigit-plus-pd1-caution/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO-25-02777>, <https://doi.org/10.1016/S1470-2045(22)00226-1> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/sclc/> ;
  onco:targets <https://onco.cc/targets/tigit/>, <https://onco.cc/targets/pdl1/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-cho-lancet-oncol/>, <https://onco.cc/key-papers/paper-peters-j-clin-oncol/> ;
  onco:pairs <https://onco.cc/targets/tigit/>, <https://onco.cc/technologies/checkpoint-inhibitor/> .