# OnCo record tim3 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tim3/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tim3" ;
  schema:name "TIM-3"@en ;
  schema:description "An immune checkpoint on exhausted T cells and on leukaemic stem cells; antibodies against it failed in lung cancer and MDS after strong preclinical promise."@en ;
  schema:url <https://onco.cc/targets/tim3/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/HAVCR2>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18437>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135077>, <https://www.uniprot.org/uniprotkb/Q8TDQ0/entry>, <https://www.ncbi.nlm.nih.gov/gene/84868> ;
  owl:sameAs <http://www.wikidata.org/entity/Q18047821> ;
  schema:citation <https://doi.org/10.1016/S2352-3026(23)00333-2> ;
  onco:tag "gap-fill", "negative-trials" ;
  schema:alternateName "HAVCR2" ;
  onco:targetClass "checkpoint" ;
  onco:firstDescribed "2000"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/lag3/>, <https://onco.cc/targets/tigit/>, <https://onco.cc/targets/pd1/> ;
  onco:cancers <https://onco.cc/cancers/mds/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/tim3-blockade/> ;
  onco:drugs <https://onco.cc/drugs/azd7789/>, <https://onco.cc/drugs/lb1410/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/t-cell-exhaustion/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-zeidan-lancet-haematol/> .