# OnCo record tiragolumab (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/tiragolumab/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "tiragolumab" ;
  schema:name "Tiragolumab"@en ;
  schema:description "An immune-brake blocker that looked excellent in a phase 2 lung cancer trial and then failed every phase 3."@en ;
  schema:url <https://onco.cc/drugs/tiragolumab/> ;
  schema:dateModified "2026-09-06"^^xsd:date ;
  schema:citation <https://www.roche.com/media/releases/med-cor-2024-11-26> ;
  onco:status "negative" ;
  onco:tag "failure", "lesson:phase-2-mirage" ;
  onco:modality "Monoclonal antibody (anti-TIGIT)" ;
  onco:related <https://onco.cc/pairings/tigit-plus-pd1-caution/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/sclc/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/tigit-blockade/> ;
  onco:targets <https://onco.cc/targets/tigit/>, <https://onco.cc/targets/pdl1/> ;
  onco:drugs <https://onco.cc/drugs/atezolizumab/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/> ;
  onco:trials <https://onco.cc/trials/nct05904886/>, <https://onco.cc/trials/nct05009069/>, <https://onco.cc/trials/nct05805501/>, <https://onco.cc/trials/nct04524871/>, <https://onco.cc/trials/nct05645692/>, <https://onco.cc/trials/nct04665856/> .