# OnCo record tissue-organisation-field-theory (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/tissue-organisation-field-theory/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "tissue-organisation-field-theory" ;
  schema:name "Tissue organisation field theory (Sonnenschein and Soto)"@en ;
  schema:alternateName "TOFT"@en, "tissue organization field theory"@en, "tissue organisation field theory of carcinogenesis"@en, "tissue-based theory of cancer"@en ;
  schema:description "Carlos Sonnenschein and Ana Soto argue that cancer is a disease of tissue architecture, not of single cells: carcinogens disrupt the conversation between a tissue's supporting stroma and its lining cells, and disordered growth follows as in a wound or an embryo gone wrong. Mutations are consequences. Their rat experiments are real, but the theory has few followers and no drug of its own."@en ;
  schema:url <https://onco.cc/terms/tissue-organisation-field-theory/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Carcinogenesis> ;
  schema:citation <https://doi.org/10.1016/j.semcancer.2008.03.012>, <https://doi.org/10.1002/bies.201100025>, <https://doi.org/10.1242/jcs.01000>, <https://doi.org/10.1083/jcb.137.1.231>, <https://doi.org/10.1038/nm.2328> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/somatic-mutation-theory/>, <https://onco.cc/terms/microenvironment-inflammation-theory/>, <https://onco.cc/terms/mechanical-theory-of-cancer/>, <https://onco.cc/terms/bioelectric-theory-of-cancer/>, <https://onco.cc/terms/hallmarks-synthesis/>, <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/terms/cancer-associated-fibroblasts/>, <https://onco.cc/pathways/basement-membrane-tissue-barriers/> ;
  onco:pathways <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/pathways/basement-membrane-tissue-barriers/> ;
  onco:terms <https://onco.cc/terms/cancer-associated-fibroblasts/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-weaver-j-cell-biol/>, <https://onco.cc/key-papers/paper-sonnenschein-semin-cancer-biol/>, <https://onco.cc/key-papers/paper-soto-bioessays/>, <https://onco.cc/key-papers/paper-bissell-nat-med/>, <https://onco.cc/key-papers/paper-maffini-j-cell-sci/> .