# OnCo record tnbc-mesenchymal (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/tnbc-mesenchymal/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "tnbc-mesenchymal" ;
  schema:name "Mesenchymal triple-negative breast cancer (M)"@en ;
  schema:alternateName "M subtype"@en, "Mesenchymal TNBC"@en, "MES subtype (Burstein)"@en, "Claudin-low triple-negative breast cancer (overlapping phenotype)"@en ;
  schema:description "Mesenchymal triple-negative breast cancers have switched on the programme cells use to migrate (epithelial-to-mesenchymal transition). They overlap with claudin-low and metaplastic tumours, respond to chemotherapy less well than basal-like 1 tumours, and are the subtype the parent page names as resisting every drug class."@en ;
  schema:url <https://onco.cc/cancers/tnbc-mesenchymal/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Triple-negative_breast_cancer> ;
  schema:citation <https://doi.org/10.1172/jci45014>, <https://doi.org/10.1371/journal.pone.0157368>, <https://doi.org/10.1158/1078-0432.ccr-14-0432>, <https://doi.org/10.1186/bcr2635>, <https://doi.org/10.1038/s41467-020-15574-5> ;
  onco:tag "breast", "tnbc", "subtype-page" ;
  onco:related <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/tnbc-mesenchymal-stem-like/>, <https://onco.cc/cancers/metaplastic-breast-carcinoma/>, <https://onco.cc/cancers/tnbc-basal-like-2/> ;
  onco:pathways <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/pi3k-akt-mtor/> ;
  onco:terms <https://onco.cc/terms/claudin-low/>, <https://onco.cc/terms/basal-like/> ;
  onco:standardOfCare <https://onco.cc/trials/keynote-522/>, <https://onco.cc/drugs/pembrolizumab/> .