# OnCo record tnfrsf18 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tnfrsf18/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tnfrsf18" ;
  schema:name "GITR (TNFRSF18)"@en ;
  schema:alternateName "GITR"@en, "AITR"@en, "CD357"@en, "TNF receptor superfamily member 18"@en, "TNFRSF18" ;
  schema:description "GITR is an accelerator on T cells that agonist antibodies tried to press to boost immunotherapy. Several reached early trials; one programme was dropped for reasons unrelated to safety."@en ;
  schema:url <https://onco.cc/targets/tnfrsf18/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11914>, <https://www.uniprot.org/uniprotkb/Q9Y5U5/entry>, <https://www.ncbi.nlm.nih.gov/gene/8784>, <https://clinicaltrials.gov/study/NCT02598960> ;
  onco:tag "checkpoint-map" ;
  onco:targetClass "surface-antigen" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11914>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186891>, <https://www.uniprot.org/uniprotkb/Q9Y5U5/entry>, <https://www.ncbi.nlm.nih.gov/gene/8784> ;
  onco:related <https://onco.cc/targets/tnfrsf4/>, <https://onco.cc/targets/cd137/>, <https://onco.cc/drugs/nivolumab/> ;
  onco:pathways <https://onco.cc/pathways/cancer-immunity-cycle/> .