# OnCo record tnfrsf4 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tnfrsf4/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tnfrsf4" ;
  schema:name "OX40 (TNFRSF4)"@en ;
  schema:alternateName "OX40"@en, "CD134"@en, "ACT35"@en, "TNF receptor superfamily member 4"@en, "TNFRSF4" ;
  schema:description "OX40 is an accelerator that appears on T cells once they are switched on; pressing it makes them multiply and survive longer. Agonist antibodies against it are in trials, including a phase 3 in head and neck cancer."@en ;
  schema:url <https://onco.cc/targets/tnfrsf4/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11918>, <https://www.uniprot.org/uniprotkb/P43489/entry>, <https://www.ncbi.nlm.nih.gov/gene/7293>, <https://europepmc.org/article/MED/19538134> ;
  onco:tag "checkpoint-map" ;
  onco:targetClass "surface-antigen" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11918>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186827>, <https://www.uniprot.org/uniprotkb/P43489/entry>, <https://www.ncbi.nlm.nih.gov/gene/7293> ;
  onco:related <https://onco.cc/targets/cd137/>, <https://onco.cc/targets/tnfrsf18/>, <https://onco.cc/drugs/pembrolizumab/> ;
  onco:drugs <https://onco.cc/drugs/inbrx-106/> ;
  onco:pathways <https://onco.cc/pathways/cancer-immunity-cycle/> .