# OnCo record tocilizumab (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/tocilizumab/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "tocilizumab" ;
  schema:name "Tocilizumab"@en ;
  schema:alternateName "RoActemra"@en, "Tofidence"@en, "Tyenne"@en, "Actemra" ;
  schema:description "Tocilizumab (Actemra) is a rheumatoid arthritis antibody that has become the rescue drug for cytokine release syndrome, the fever and blood-pressure crash that CAR-T cells and bispecific antibodies can trigger. Every CAR-T centre must have it on hand."@en ;
  schema:url <https://onco.cc/drugs/tocilizumab/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Tocilizumab> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=tocilizumab>, <https://www.cancer.gov/about-cancer/treatment/drugs/tocilizumab> ;
  onco:status "approved" ;
  onco:tag "nci-list", "supportive" ;
  onco:modality "Monoclonal antibody (anti-IL-6 receptor, humanised IgG1)" ;
  onco:approval "US 2010: Rheumatoid arthritis (first approval)", "US 2017: Severe or life-threatening CAR-T-cell-induced cytokine release syndrome, age 2 and over" ;
  onco:related <https://onco.cc/drugs/siltuximab/>, <https://onco.cc/drugs/tisagenlecleucel/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/t-cell-engager/>, <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/il6/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/> ;
  onco:trials <https://onco.cc/trials/nct07589634/>, <https://onco.cc/trials/nct04077723/>, <https://onco.cc/trials/nct05583617/>, <https://onco.cc/trials/nct05535244/>, <https://onco.cc/trials/nct04246086/>, <https://onco.cc/trials/nct05207670/>, <https://onco.cc/trials/nct03075696/>, <https://onco.cc/trials/nct03671018/>, <https://onco.cc/trials/nct04524871/>, <https://onco.cc/trials/nct06084936/>, <https://onco.cc/trials/nct03533283/>, <https://onco.cc/trials/nct04980222/> .