# OnCo record top1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/top1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "top1" ;
  schema:name "Topoisomerase I (TOP1)"@en ;
  schema:description "The enzyme that nicks one DNA strand to relieve twisting while DNA is copied. Camptothecins and the payloads of several antibody-drug conjugates trap it on the DNA so the nick becomes a permanent break when the cell replicates."@en ;
  schema:url <https://onco.cc/targets/top1/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/TOP1>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11986>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198900>, <https://www.uniprot.org/uniprotkb/P11387/entry>, <https://www.ncbi.nlm.nih.gov/gene/7150> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P11387/entry> ;
  schema:alternateName "TOP1" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1988"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/breast-her2-positive/> ;
  onco:drugs <https://onco.cc/drugs/irinotecan/>, <https://onco.cc/drugs/topotecan/>, <https://onco.cc/drugs/sacituzumab-govitecan/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:trials <https://onco.cc/trials/nct06797999/> .