# OnCo record topoisomerase-i-payloads (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/topoisomerase-i-payloads/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "topoisomerase-i-payloads" ;
  schema:name "Topoisomerase-I inhibitor payloads"@en ;
  schema:alternateName "camptothecin payloads"@en, "TOP1 payloads"@en ;
  schema:description "Topoisomerase-I inhibitor payloads are the payload class behind Enhertu, Trodelvy and Dato-DXd: poisons that trap the enzyme that untwists DNA, so dividing cells break their own DNA."@en ;
  schema:url <https://onco.cc/terms/topoisomerase-i-payloads/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Camptothecin> ;
  schema:citation <https://en.wikipedia.org/wiki/Camptothecin> ;
  onco:related <https://onco.cc/technologies/topoisomerase-inhibitors/>, <https://onco.cc/terms/adc-sequencing/>, <https://onco.cc/terms/efflux-pump/>, <https://onco.cc/terms/bystander-effect/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/sacituzumab-govitecan/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/datopotamab-deruxtecan/>, <https://onco.cc/drugs/patritumab-deruxtecan/>, <https://onco.cc/drugs/ifinatamab-deruxtecan/>, <https://onco.cc/drugs/raludotatug-deruxtecan/>, <https://onco.cc/drugs/izalontamab-brengitecan/>, <https://onco.cc/drugs/tilatamig-samrotecan/>, <https://onco.cc/drugs/ak146d1/>, <https://onco.cc/drugs/puxitatug-samrotecan/>, <https://onco.cc/drugs/sacituzumab-tirumotecan/> ;
  onco:terms <https://onco.cc/terms/payload/> .