# OnCo record topoisomerase-inhibitors (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/topoisomerase-inhibitors/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "topoisomerase-inhibitors" ;
  schema:name "Topoisomerase-I inhibitors (and ADC payloads)"@en ;
  schema:description "Topoisomerase-I inhibitors jam the enzyme that untangles DNA during copying, causing double-strand breaks. As free drugs (irinotecan, topotecan) they are modest, but their analogues SN-38 and deruxtecan are the dominant antibody-drug conjugate payload class of the 2020s, active after taxane failure; cross-resistance between these ADCs is a growing problem."@en ;
  schema:url <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Topoisomerase_inhibitor> ;
  owl:sameAs <http://www.wikidata.org/entity/Q281044> ;
  schema:citation <https://en.wikipedia.org/wiki/Topoisomerase_inhibitor> ;
  onco:status "standard-of-care" ;
  onco:sections <https://onco.cc/fronts/chemotherapy/>, <https://onco.cc/fronts/adcs/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:companies <https://onco.cc/companies/dantari/>, <https://onco.cc/companies/pheon-therapeutics/>, <https://onco.cc/companies/profoundbio/>, <https://onco.cc/companies/sunesis/> ;
  onco:terms <https://onco.cc/terms/payload/>, <https://onco.cc/terms/bystander-effect/> .