# OnCo record topotecan (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/topotecan/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "topotecan" ;
  schema:name "Topotecan"@en ;
  schema:description "Topotecan is the long-standing second-line chemotherapy for relapsed small-cell lung cancer, and now the comparator that new drugs must beat."@en ;
  schema:url <https://onco.cc/drugs/topotecan/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Topotecan> ;
  owl:sameAs <http://www.wikidata.org/entity/Q419953> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Topotecan>, <https://www.nice.org.uk/guidance/ta184> ;
  onco:status "approved" ;
  onco:modality "Cytotoxic (topoisomerase-I inhibitor)" ;
  schema:alternateName "Hycamtin" ;
  onco:approval "US 1996: Relapsed SCLC (IV)", "US 2007: Relapsed SCLC (oral)", "England (NICE) 2009: Relapsed small-cell lung cancer, oral topotecan, only where re-treatment with the first-line regimen is inappropriate and cyclophosphamide, doxorubicin and vincristine is contraindicated" ;
  onco:cancers <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/cervical/>, <https://onco.cc/cancers/extensive-stage-sclc/> ;
  onco:technologies <https://onco.cc/technologies/topoisomerase-inhibitors/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:companies <https://onco.cc/companies/gsk/>, <https://onco.cc/companies/novartis/> ;
  onco:trials <https://onco.cc/trials/dellphi-304/>, <https://onco.cc/trials/atlantis/>, <https://onco.cc/trials/ideate-lung02/>, <https://onco.cc/trials/nct06828354/>, <https://onco.cc/trials/nct06801834/>, <https://onco.cc/trials/nct06459180/>, <https://onco.cc/trials/nct07604766/>, <https://onco.cc/trials/nct06496048/>, <https://onco.cc/trials/nct06619236/>, <https://onco.cc/trials/nct06128837/>, <https://onco.cc/trials/nct06500026/>, <https://onco.cc/trials/nct03709680/>, <https://onco.cc/trials/nct06449209/>, <https://onco.cc/trials/nct07099898/>, <https://onco.cc/trials/nct06679634/>, <https://onco.cc/trials/nct07145333/>, <https://onco.cc/trials/nct07286266/>, <https://onco.cc/trials/lurbinectedin-basket-sclc/> .