# OnCo record tp53-mutated (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/tp53-mutated/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "tp53-mutated" ;
  schema:name "TP53-mutated (p53-abnormal)"@en ;
  schema:alternateName "TP53-mutated"@en, "TP53-mutant"@en, "TP53 mutation"@en, "TP53 mutations"@en, "TP53 loss"@en, "TP53-altered"@en, "p53abn"@en, "p53-abnormal"@en, "p53 abnormal"@en, "p53-mutant"@en, "mutant p53"@en, "TP53/RB1"@en, "TP53 and RB1"@en, "multi-hit TP53"@en ;
  schema:description "Loss of the p53 'guardian of the genome', the most commonly mutated gene in cancer. In blood cancers and several solid tumours a TP53 mutation marks the highest-risk group, resistant to chemotherapy and hard to treat."@en ;
  schema:url <https://onco.cc/terms/tp53-mutated/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/P53> ;
  schema:citation <https://en.wikipedia.org/wiki/P53> ;
  onco:related <https://onco.cc/terms/wild-type/>, <https://onco.cc/terms/cytogenetics/>, <https://onco.cc/terms/li-fraumeni/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/ovarian/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/mdm2/> .