# OnCo record tp53 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tp53/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tp53" ;
  schema:name "TP53"@en ;
  schema:description "TP53 is the 'guardian of the genome', broken in half of all cancers. Fixing it directly has so far defeated every attempt, so drugs exploit what its loss makes cancers depend on."@en ;
  schema:url <https://onco.cc/targets/tp53/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/P53>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141510>, <https://www.uniprot.org/uniprotkb/P04637/entry>, <https://www.ncbi.nlm.nih.gov/gene/7157> ;
  owl:sameAs <http://www.wikidata.org/entity/Q283350> ;
  schema:citation <https://en.wikipedia.org/wiki/P53>, <https://doi.org/10.1182/blood-2017-04-779736>, <https://doi.org/10.1182/blood-2010-09-302174> ;
  onco:tag "tumour-suppressor", "undrugged" ;
  schema:alternateName "TP53" ;
  onco:targetClass "tumor-suppressor" ;
  onco:firstDescribed "1984"^^xsd:gYear ;
  onco:related <https://onco.cc/biomarkers/tp53-del17p/> ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:drugs <https://onco.cc/drugs/ose2101/>, <https://onco.cc/drugs/krt-232/> ;
  onco:companies <https://onco.cc/companies/bulsara-bioworks/>, <https://onco.cc/companies/nested-therapeutics/>, <https://onco.cc/companies/photys-therapeutics/> ;
  onco:pathways <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/basal-cell-carcinoma-signalling/>, <https://onco.cc/pathways/breast-cancer-signalling/>, <https://onco.cc/pathways/cml-signalling/>, <https://onco.cc/pathways/colorectal-cancer-signalling/>, <https://onco.cc/pathways/endometrial-cancer-signalling/>, <https://onco.cc/pathways/gastric-cancer-signalling/>, <https://onco.cc/pathways/hepatocellular-carcinoma-signalling/>, <https://onco.cc/pathways/micrornas-in-cancer/>, <https://onco.cc/pathways/nsclc-signalling/>, <https://onco.cc/pathways/pancreatic-cancer-signalling/>, <https://onco.cc/pathways/sclc-signalling/>, <https://onco.cc/pathways/thyroid-cancer-signalling/>, <https://onco.cc/pathways/p53-mdm2-axis/>, <https://onco.cc/pathways/chromosomal-instability/> ;
  onco:trials <https://onco.cc/trials/nct07060989/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/>, <https://onco.cc/key-papers/paper-tcga-breast-molecular-portraits-nature-2012/>, <https://onco.cc/key-papers/paper-bareche-tnbc-multiomic-heterogeneity-ann-oncol-2018/>, <https://onco.cc/key-papers/paper-shah-tnbc-clonal-evolution-nature-2012/>, <https://onco.cc/key-papers/paper-philip-kras-wild-type-pancreatic-ccr-2022/>, <https://onco.cc/key-papers/paper-bailey-molecular-subtypes-pancreatic-nature-2016/>, <https://onco.cc/key-papers/paper-qian-driver-genes-outcomes-resected-pancreatic-jama-oncol-2018/>, <https://onco.cc/key-papers/paper-luchini-msi-dmmr-pancreatic-systematic-review-gut-2021/>, <https://onco.cc/key-papers/paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988/>, <https://onco.cc/key-papers/paper-giraldo-gallbladder-msk-impact-ccr-2022/>, <https://onco.cc/key-papers/paper-javle-biliary-ngs-cancer-2016/>, <https://onco.cc/key-papers/paper-suryavanshi-indian-gallbladder-genomics-jco-go-2025/>, <https://onco.cc/key-papers/paper-li-gallbladder-exome-erbb-nat-genet-2014/>, <https://onco.cc/key-papers/paper-erices-chilean-gallbladder-landscape-front-oncol-2025/>, <https://onco.cc/key-papers/paper-nepal-gallbladder-microenvironment-subtypes-j-hepatol-2021/>, <https://onco.cc/key-papers/paper-alexandrov-tobacco-smoking-mutational-signatures-science-2016/>, <https://onco.cc/key-papers/paper-zhang-lung-cancer-never-smokers-nat-genet-2021/>, <https://onco.cc/key-papers/paper-tcga-lung-squamous-nature-2012/>, <https://onco.cc/key-papers/paper-george-sclc-genomic-profiles-nature-2015/>, <https://onco.cc/key-papers/paper-mateo-genomics-lethal-prostate-diagnosis-castration-resistance-jci-2020/> .