# OnCo record tph1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tph1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tph1" ;
  schema:name "Tryptophan hydroxylase 1"@en ;
  schema:description "Tryptophan hydroxylase makes serotonin, the hormone that neuroendocrine tumours pour out in carcinoid syndrome; telotristat ethyl blocks the enzyme to cut the diarrhoea that somatostatin analogues leave uncontrolled."@en ;
  schema:url <https://onco.cc/targets/tph1/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Tryptophan_hydroxylase_1>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12008>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000129167>, <https://www.uniprot.org/uniprotkb/P17752/entry>, <https://www.ncbi.nlm.nih.gov/gene/7166> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P17752/entry>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12008>, <https://www.ebi.ac.uk/chembl/explore/target/CHEMBL3831287> ;
  onco:tag "chembl-gap" ;
  schema:alternateName "TPH1" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1990"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/sstr2/> ;
  onco:cancers <https://onco.cc/cancers/neuroendocrine/> ;
  onco:drugs <https://onco.cc/drugs/telotristat-ethyl/> ;
  onco:terms <https://onco.cc/terms/carcinoid-syndrome/> .