# OnCo record train-2 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/train-2/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "train-2", "NCT01996267" ;
  schema:name "TRAIN-2"@en ;
  schema:description "TRAIN-2 showed that HER2-positive breast cancer can be treated before surgery without an anthracycline: carboplatin and paclitaxel with the two HER2 antibodies made the tumour disappear as often as an anthracycline regimen did, with less harm to the heart."@en ;
  schema:url <https://onco.cc/trials/train-2/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01996267>, <https://doi.org/10.1016/S1470-2045(18)30570-9> ;
  onco:status "positive" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/her2-positive-early-breast-cancer/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/pertuzumab/>, <https://onco.cc/drugs/epirubicin/>, <https://onco.cc/drugs/cyclophosphamide/> ;
  onco:terms <https://onco.cc/terms/pcr/>, <https://onco.cc/terms/dual-her2-blockade/> .