# OnCo record trastuzumab-duocarmazine (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/trastuzumab-duocarmazine/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "trastuzumab-duocarmazine" ;
  schema:name "Trastuzumab duocarmazine"@en ;
  schema:description "A HER2 ADC with a DNA-alkylating payload that beat chemotherapy in a phase 3 trial yet never reached the market, because eye and lung toxicity and a stronger rival arrived first."@en ;
  schema:url <https://onco.cc/drugs/trastuzumab-duocarmazine/> ;
  schema:dateModified "2026-09-06"^^xsd:date ;
  schema:citation <https://www.annalsofoncology.org/article/S0923-7534(21)04434-8/fulltext> ;
  onco:status "withdrawn" ;
  onco:tag "failure", "lesson:toxicity" ;
  onco:modality "ADC" ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:companies <https://onco.cc/companies/byondis/> ;
  onco:trials <https://onco.cc/trials/nct03262935/>, <https://onco.cc/trials/nct04205630/>, <https://onco.cc/trials/i-spy-2-2/> .