# OnCo record treetopp (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/treetopp/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "treetopp", "NCT03093870" ;
  schema:name "TreeTopp"@en ;
  schema:description "TreeTopp tested whether the HER-family blocker varlitinib added to capecitabine helps bile duct and gallbladder cancer after first-line chemotherapy. It did not: response, progression and survival were the same, and the planned phase 3 part was abandoned. A small gallbladder subgroup hinted at slower progression but the finding was not conclusive."@en ;
  schema:url <https://onco.cc/trials/treetopp/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03093870>, <https://doi.org/10.1016/j.esmoop.2021.100314> ;
  onco:status "negative" ;
  onco:tag "failure" ;
  onco:phase "2/3" ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/biliary-tract-cancer/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/varlitinib/>, <https://onco.cc/drugs/capecitabine/> .