# OnCo record tsc2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tsc2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tsc2" ;
  schema:name "TSC2"@en ;
  schema:alternateName "TSC complex subunit 2"@en, "Tuberin"@en, "tuberin"@en, "PPP1R160"@en, "TSC4"@en, "TSC2" ;
  schema:description "TSC2 (Tuberin) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Hepatocellular carcinoma, Renal cell carcinoma, Thyroid cancer and 5 more."@en ;
  schema:url <https://onco.cc/targets/tsc2/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12363>, <https://www.uniprot.org/uniprotkb/P49815/entry>, <https://www.ncbi.nlm.nih.gov/gene/7249>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103197> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "tumor-suppressor" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12363>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103197>, <https://www.uniprot.org/uniprotkb/P49815/entry>, <https://www.ncbi.nlm.nih.gov/gene/7249> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/thyroid/>, <https://onco.cc/cancers/neuroendocrine/>, <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/gastric/> ;
  onco:drugs <https://onco.cc/drugs/sirolimus-albumin-bound/> ;
  onco:trials <https://onco.cc/trials/nct05103358/> .