# OnCo record tumor-microenvironment (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/tumor-microenvironment/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "tumor-microenvironment" ;
  schema:name "Tumour microenvironment (TME)"@en ;
  schema:description "A tumour is not just cancer cells. It is a neighbourhood of fibroblasts, immune cells, blood vessels, nerves, and scaffolding that the cancer recruits and corrupts, and that decides whether drugs and immune cells can get in."@en ;
  schema:url <https://onco.cc/pathways/tumor-microenvironment/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Tumor_microenvironment> ;
  owl:sameAs <http://www.wikidata.org/entity/Q1786433> ;
  schema:citation <https://doi.org/10.1016/j.ccell.2023.02.016>, <https://humantumoratlas.org> ;
  onco:tag "mechanism" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/microenvironment-inflammation-theory/>, <https://onco.cc/terms/tissue-organisation-field-theory/> ;
  onco:technologies <https://onco.cc/technologies/single-cell-spatial/>, <https://onco.cc/technologies/fapi-pet/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/antiangiogenic/> ;
  onco:targets <https://onco.cc/targets/fap/>, <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/vegf/>, <https://onco.cc/targets/cd47/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/md-anderson/>, <https://onco.cc/institutions/cold-spring-harbor/>, <https://onco.cc/institutions/dana-farber/>, <https://onco.cc/institutions/institut-curie/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/vegf-angiogenesis/>, <https://onco.cc/pathways/cgas-sting/>, <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/cancer-neuroscience/>, <https://onco.cc/pathways/inflammation-nfkb/> ;
  onco:terms <https://onco.cc/terms/cold-vs-hot/>, <https://onco.cc/terms/tils/>, <https://onco.cc/terms/cancer-associated-fibroblasts/>, <https://onco.cc/terms/tumor-associated-macrophages/>, <https://onco.cc/terms/myeloid-derived-suppressor-cells/>, <https://onco.cc/terms/immune-exclusion/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-quail-joyce-microenvironment-metastasis-natmed-2013/>, <https://onco.cc/key-papers/paper-de-visser-cancer-cell/> .