# OnCo record tuxedo-1 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/tuxedo-1/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "tuxedo-1", "NCT04752059" ;
  schema:name "TUXEDO-1"@en ;
  schema:description "TUXEDO-1 was a small study that showed trastuzumab deruxtecan shrinks brain metastases in most people with HER2-positive breast cancer, overturning the assumption that large antibody-drug conjugates cannot work inside the brain."@en ;
  schema:url <https://onco.cc/trials/tuxedo-1/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04752059> ;
  onco:status "positive" ;
  onco:tag "subtype-trials" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/her2-positive-breast-brain-metastases/>, <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/breast-cancer/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:people <https://onco.cc/people/rupert-bartsch/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-tuxedo-1-trastuzumab-deruxtecan-brain-metastases-nat-med-2022/> .