# OnCo record tyms (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/tyms/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "tyms" ;
  schema:name "Thymidylate synthase (TYMS)"@en ;
  schema:description "The enzyme that makes the thymine building block of DNA. Fluorouracil, capecitabine and pemetrexed jam it, starving dividing cells of thymidine."@en ;
  schema:url <https://onco.cc/targets/tyms/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Thymidylate_synthase>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12441>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000176890>, <https://www.uniprot.org/uniprotkb/P04818/entry>, <https://www.ncbi.nlm.nih.gov/gene/7298> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P04818/entry> ;
  schema:alternateName "TYMS" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1985"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:drugs <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/capecitabine/>, <https://onco.cc/drugs/pemetrexed/> .