# OnCo record ubiquitin-proteasome-system (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/ubiquitin-proteasome-system/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "ubiquitin-proteasome-system" ;
  schema:name "Ubiquitin-proteasome system & protein homeostasis"@en ;
  schema:description "Cells tag unwanted proteins with a small marker called ubiquitin and feed them into a shredder, the proteasome. Myeloma cells, which make antibody in bulk, die if the shredder jams; and the newest drugs hijack the tagging machinery to make a cancer destroy its own oncoproteins."@en ;
  schema:url <https://onco.cc/pathways/ubiquitin-proteasome-system/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Proteasome> ;
  schema:citation <https://doi.org/10.1038/s41573-021-00371-6> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/mantle-cell-lymphoma/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/molecular-glue-platforms/>, <https://onco.cc/technologies/degrader-antibody-conjugate/> ;
  onco:targets <https://onco.cc/targets/mdm2/>, <https://onco.cc/targets/hif2a/>, <https://onco.cc/targets/estrogen-receptor/>, <https://onco.cc/targets/btk/>, <https://onco.cc/targets/bcma/>, <https://onco.cc/targets/androgen-receptor/> ;
  onco:drugs <https://onco.cc/drugs/bortezomib/>, <https://onco.cc/drugs/carfilzomib/>, <https://onco.cc/drugs/ixazomib/>, <https://onco.cc/drugs/lenalidomide/>, <https://onco.cc/drugs/pomalidomide/>, <https://onco.cc/drugs/iberdomide/>, <https://onco.cc/drugs/mezigdomide/>, <https://onco.cc/drugs/golcadomide/>, <https://onco.cc/drugs/vepdegestrant/>, <https://onco.cc/drugs/bgb-16673/> ;
  onco:pathways <https://onco.cc/pathways/hif-vhl/>, <https://onco.cc/pathways/p53-mdm2-axis/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/pathways/myc/> ;
  onco:terms <https://onco.cc/terms/r-iss/>, <https://onco.cc/terms/high-risk-myeloma/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-bekes-nat-rev-drug-discov/> .