# OnCo record uveal-melanoma-prognostic-markers (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/uveal-melanoma-prognostic-markers/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "uveal-melanoma-prognostic-markers" ;
  schema:name "Uveal melanoma prognostic markers (GNAQ/GNA11, monosomy 3, gene-expression class)"@en ;
  schema:alternateName "GNAQ"@en, "GNA11"@en, "GNAQ/GNA11 mutation"@en, "monosomy 3"@en, "chromosome 3 loss"@en, "disomy 3"@en, "8q gain"@en, "DecisionDx-UM"@en, "gene expression profile class 1"@en, "class 2 uveal melanoma"@en, "GEP class 1"@en, "GEP class 2"@en, "PRAME expression"@en, "EIF1AX"@en, "PLCB4"@en, "CYSLTR2"@en, "uveal melanoma genetics"@en ;
  schema:description "Nearly all eye melanomas start with a mutation in GNAQ or GNA11, which is why skin-melanoma drugs do not work on them; what decides whether the tumour will spread to the liver is a second layer: loss of chromosome 3 with BAP1 mutation and a class 2 gene-expression profile mean high risk, while EIF1AX or SF3B1 mutations and class 1 mean low or delayed risk."@en ;
  schema:url <https://onco.cc/terms/uveal-melanoma-prognostic-markers/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  onco:related <https://onco.cc/terms/bap1-loss/>, <https://onco.cc/terms/hla-a02-restriction/>, <https://onco.cc/drugs/tebentafusp/>, <https://onco.cc/drugs/brenetafusp/>, <https://onco.cc/targets/prame/>, <https://onco.cc/terms/sf3b1-mutation/>, <https://onco.cc/terms/fish/>, <https://onco.cc/terms/gene-expression/> ;
  onco:cancers <https://onco.cc/cancers/uveal-melanoma/> .