# OnCo record varlitinib (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/varlitinib/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "varlitinib" ;
  schema:name "Varlitinib"@en ;
  schema:description "A pill that blocked the HER family of growth receptors, tested with capecitabine as second-line treatment for bile duct and gallbladder cancer. It did not beat capecitabine alone in the TreeTopp trial and development stopped."@en ;
  schema:url <https://onco.cc/drugs/varlitinib/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.esmoop.2021.100314>, <https://clinicaltrials.gov/study/NCT03093870> ;
  onco:status "historic" ;
  onco:tag "failure" ;
  onco:modality "Small-molecule reversible pan-HER kinase inhibitor (EGFR, HER2, HER4)" ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/cholangiocarcinoma/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/her2/> ;
  onco:trials <https://onco.cc/trials/treetopp/> .