# OnCo record vemurafenib (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/vemurafenib/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "vemurafenib" ;
  schema:name "Vemurafenib"@en ;
  schema:description "Vemurafenib was the first BRAF inhibitor (2011); it shrank melanomas in weeks and proved that a single mutation could be drugged in a solid tumour."@en ;
  schema:url <https://onco.cc/drugs/vemurafenib/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Vemurafenib> ;
  owl:sameAs <http://www.wikidata.org/entity/Q423111> ;
  schema:citation <https://www.nejm.org/doi/full/10.1056/NEJMoa1103782> ;
  onco:status "approved" ;
  onco:modality "Small-molecule kinase inhibitor (BRAF V600)" ;
  schema:alternateName "Zelboraf" ;
  onco:approval "US 2011: Unresectable or metastatic BRAF V600E melanoma", "US 2017: Erdheim-Chester disease with BRAF V600 mutation" ;
  onco:related <https://onco.cc/biomarkers/braf-v600e/> ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/braf-v600-melanoma/>, <https://onco.cc/cancers/advanced-melanoma/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/braf-v600e-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/braf/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:trials <https://onco.cc/trials/columbus/>, <https://onco.cc/trials/nct04302025/>, <https://onco.cc/trials/swog-s1406/> .