# OnCo record ventana-pd-l1-sp142 (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/ventana-pd-l1-sp142/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "ventana-pd-l1-sp142" ;
  schema:name "VENTANA PD-L1 (SP142) Assay"@en ;
  schema:description "The PD-L1 stain that decides who can have atezolizumab, scored on immune cells rather than tumour cells in breast cancer."@en ;
  schema:url <https://onco.cc/drugs/ventana-pd-l1-sp142/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P160002> ;
  onco:status "approved" ;
  onco:tag "test" ;
  onco:modality "PD-L1 immunohistochemistry companion diagnostic assay" ;
  schema:alternateName "VENTANA PD-L1 (SP142)" ;
  onco:approval "US 2016: PD-L1 expression to inform atezolizumab treatment in urothelial carcinoma (later NSCLC)", "US 2019: Companion diagnostic for atezolizumab in PD-L1 IC ≥1% triple-negative breast cancer" ;
  onco:related <https://onco.cc/drugs/dako-pd-l1-22c3-pharmdx/>, <https://onco.cc/drugs/ventana-pd-l1-sp263/> ;
  onco:cancers <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/tnbc-metastatic/> ;
  onco:technologies <https://onco.cc/technologies/companion-diagnostic/>, <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:targets <https://onco.cc/targets/pdl1/> ;
  onco:drugs <https://onco.cc/drugs/atezolizumab/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/> ;
  onco:terms <https://onco.cc/terms/pd-l1-testing/>, <https://onco.cc/terms/ihc/> ;
  onco:trials <https://onco.cc/trials/impassion130/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-rugo-pd-l1-assay-comparison-impassion130-jnci-2021/>, <https://onco.cc/key-papers/paper-sigurjonsdottir-sp142-22c3-tnbc-bcr-2023/> .