# OnCo record vhl (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/vhl/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "vhl" ;
  schema:name "VHL"@en ;
  schema:alternateName "von Hippel-Lindau tumor suppressor"@en, "von Hippel-Lindau disease tumor suppressor"@en, "VHL1"@en, "VHL" ;
  schema:description "VHL (von Hippel-Lindau disease tumour suppressor) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma, Neuroendocrine tumours, Breast cancer and 5 more."@en ;
  schema:url <https://onco.cc/targets/vhl/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12687>, <https://www.uniprot.org/uniprotkb/P40337/entry>, <https://www.ncbi.nlm.nih.gov/gene/7428>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134086> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "tumor-suppressor" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12687>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134086>, <https://www.uniprot.org/uniprotkb/P40337/entry>, <https://www.ncbi.nlm.nih.gov/gene/7428> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/neuroendocrine/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/pheochromocytoma-paraganglioma/>, <https://onco.cc/cancers/clear-cell-rcc/>, <https://onco.cc/cancers/polycythaemia-vera/>, <https://onco.cc/cancers/chromophobe-rcc/> ;
  onco:pathways <https://onco.cc/pathways/hif-vhl/>, <https://onco.cc/pathways/renal-cell-carcinoma-signalling/>, <https://onco.cc/pathways/ubiquitin-proteasome-system/> ;
  onco:trials <https://onco.cc/trials/nct04924075/> .