# OnCo record vismodegib (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/vismodegib/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "vismodegib" ;
  schema:name "Vismodegib"@en ;
  schema:description "Vismodegib was the first hedgehog-pathway drug, for basal cell carcinomas too advanced for surgery; it shrinks most tumours but muscle cramps, taste loss and hair loss make long-term use hard."@en ;
  schema:url <https://onco.cc/drugs/vismodegib/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Vismodegib> ;
  owl:sameAs <http://www.wikidata.org/entity/Q2070286> ;
  schema:citation <https://doi.org/10.1056/NEJMoa1113713>, <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=vismodegib> ;
  onco:status "approved" ;
  onco:tag "gap-fill" ;
  onco:modality "Small-molecule smoothened (hedgehog) inhibitor" ;
  schema:alternateName "Erivedge" ;
  onco:approval "US 2012: Metastatic BCC or locally advanced BCC recurrent after surgery or not amenable to surgery/radiation", "EU 2013: Same" ;
  onco:cancers <https://onco.cc/cancers/basal-cell-carcinoma/>, <https://onco.cc/cancers/medulloblastoma/>, <https://onco.cc/cancers/medulloblastoma-shh/>, <https://onco.cc/cancers/locally-advanced-bcc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/hedgehog-inhibitors/> ;
  onco:targets <https://onco.cc/targets/smoothened/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/> ;
  onco:terms <https://onco.cc/terms/hedgehog-inhibitor-tolerability/> ;
  onco:trials <https://onco.cc/trials/nct06344052/>, <https://onco.cc/trials/stevie/>, <https://onco.cc/trials/vismoneo/> .