# OnCo record vista (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/vista/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "vista" ;
  schema:name "VISTA"@en ;
  schema:description "An immune checkpoint on myeloid cells that works at the acidic pH inside tumours and is a suspected escape route after PD-1 therapy; antibodies are in early trials."@en ;
  schema:url <https://onco.cc/targets/vista/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41586-019-1674-5> ;
  onco:tag "gap-fill" ;
  schema:alternateName "VSIR" ;
  onco:targetClass "checkpoint" ;
  onco:firstDescribed "2003"^^xsd:gYear ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30085>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107738>, <https://www.uniprot.org/uniprotkb/Q9H7M9/entry>, <https://www.ncbi.nlm.nih.gov/gene/64115> ;
  onco:related <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/tim3/>, <https://onco.cc/targets/lag3/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/mesothelioma/>, <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-johnston-nature/> .