# OnCo record wrn (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/wrn/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "wrn" ;
  schema:name "WRN helicase (MSI-high cancers)"@en ;
  schema:description "A DNA-unwinding enzyme that mismatch-repair-deficient cancers cannot live without; the first WRN inhibitors are in trials as a chemotherapy-free option for MSI-high tumours that fail immunotherapy."@en ;
  schema:url <https://onco.cc/targets/wrn/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Werner_syndrome_ATP-dependent_helicase>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12791>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000165392>, <https://www.uniprot.org/uniprotkb/Q14191/entry>, <https://www.ncbi.nlm.nih.gov/gene/7486> ;
  schema:citation <https://doi.org/10.1038/s41586-019-1102-x> ;
  onco:tag "gap-fill" ;
  schema:alternateName "WRN" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1996"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/gastric/> ;
  onco:technologies <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/cancer-cell-line-encyclopedias/> ;
  onco:drugs <https://onco.cc/drugs/ndi-219216/> ;
  onco:companies <https://onco.cc/companies/novartis/>, <https://onco.cc/companies/roche-genentech/>, <https://onco.cc/companies/gsk/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/synthetic-lethality/>, <https://onco.cc/terms/lynch-syndrome/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-chan-nature/> .