[{"id":"rejuv-tx-what-to-ask-for","name":"After a transplant or cell therapy: what to ask for","tldr":"The things worth asking a transplant team for, in one place: who follows you up and for how long, which screens are due at which year, what immunisations you need and when, and who to ring when something changes.","route":"/technologies/rejuv-tx-what-to-ask-for/","status":"standard-of-care","kind":"technology","schematic":{"id":"rejuv-tx-what-to-ask-for","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"follow-up","href":"/tagged/follow-up/","tip":"Every record tagged follow-up."},{"label":"summary","href":"/tagged/summary/","tip":"Every record tagged summary."}]},"sortKeys":{"year":0}},{"id":"gvhd-belumosudil-axatilimab-ibrutinib","name":"After ruxolitinib: belumosudil, axatilimab and ibrutinib in chronic GvHD","tldr":"Three more drugs are licensed for chronic GvHD that has not responded to earlier treatment. Their response rates look high, between half and three quarters, but they come from trials with no comparison group. Ibrutinib is the cautionary case: it looked good in a single-arm study and then did not beat prednisone alone when tested against placebo.","route":"/technologies/gvhd-belumosudil-axatilimab-ibrutinib/","status":"approved","kind":"technology","schematic":{"id":"gvhd-belumosudil-axatilimab-ibrutinib","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2021"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2021"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"gvhd","href":"/tagged/gvhd/","tip":"Every record tagged gvhd."},{"label":"treatment","href":"/tagged/treatment/","tip":"Every record tagged treatment."}]},"sortKeys":{"year":2021}},{"id":"rejuv-trial-allocare","name":"AlloCare: a stepped-care late-effects service after allogeneic transplant","tldr":"The gap after a transplant is not that nobody knows what should be checked, it is that no mechanism tells an individual survivor what is due. This trial tests an organised four-step late-effects service against usual care.","route":"/trials/rejuv-trial-allocare/","status":"recruiting","kind":"trial","sub":"NCT06281496","facets":{"kind":["Trial"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Trial","tip":"Landmark and current trials that define the standard of care."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"open-problem","href":"/tagged/open-problem/","tip":"Every record tagged open-problem."},{"label":"follow-up","href":"/tagged/follow-up/","tip":"Every record tagged follow-up."},{"label":"services","href":"/tagged/services/","tip":"Every record tagged services."}]},"sortKeys":{"year":0}},{"id":"anthony-nolan","name":"Anthony Nolan","tldr":"The UK stem cell register, founded in 1974, and the charity behind the clinical nurse specialists who look after transplant patients in NHS centres.","route":"/institutions/anthony-nolan/","kind":"institution","logo":"/logos/anthony-nolan.jpg","avatar":"org","sub":"London, GB","facets":{"kind":["Institution"],"cancers":["Non-Hodgkin lymphoma","Hodgkin lymphoma","Diffuse large B-cell lymphoma","Follicular lymphoma","Mantle cell lymphoma","Marginal zone lymphoma","Cutaneous T-cell lymphoma","Burkitt lymphoma","Primary CNS lymphoma","Peripheral T-cell lymphomas","Waldenström macroglobulinaemia","Acute myeloid leukaemia","Acute lymphoblastic leukaemia","Chronic lymphocytic leukaemia"],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[{"label":"Non-Hodgkin lymphoma","href":"/cancers/non-hodgkin-lymphoma/","tip":"Non-Hodgkin lymphoma is not one disease but a family of more than sixty cancers of the lymphocytes, the white blood cells of the immune system. About 95 per cent come from B cells and the rest from T or NK cells; some grow over years and are watched, others grow over weeks and are treated to cure. The family is the map; the subtype is the disease, and the subtype is what decides the treatment."},{"label":"Hodgkin lymphoma","href":"/cancers/hodgkin-lymphoma/","tip":"Hodgkin lymphoma is one of the most curable cancers, where the goal is now to cure with less toxicity, using brentuximab and, from 2026, first-line nivolumab."},{"label":"Diffuse large B-cell lymphoma","href":"/cancers/dlbcl/","tip":"Diffuse large B-cell lymphoma (DLBCL) is an aggressive but curable lymphoma. CAR-T cures about 40% of relapsed patients, and off-the-shelf bispecifics are now approved."},{"label":"Follicular lymphoma","href":"/cancers/follicular-lymphoma/","tip":"Follicular lymphoma is the most common slow-growing lymphoma, with a rearrangement of the BCL2 gene in more than 90% of cases (NCI PDQ). Most people live with it for decades, treated only when it causes problems; it can be controlled repeatedly with anti-CD20 antibodies, chemotherapy, bispecifics or CAR-T but rarely cured, and a small share transform into an aggressive lymphoma each year."}],"tags":[{"label":"charity","href":"/tagged/charity/","tip":"Every record tagged charity."},{"label":"uk","href":"/tagged/uk/","tip":"Every record tagged uk."},{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"incucai-hsc-donor-registry","name":"Argentine Registry of Haematopoietic Stem Cell Donors (INCUCAI)","tldr":"Argentina's national register of blood stem cell donors, run by INCUCAI, the national agency that coordinates organ, tissue and cell donation and transplantation.","route":"/institutions/incucai-hsc-donor-registry/","kind":"institution","avatar":"org","sub":"Buenos Aires, AR","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-b-cell-aplasia-and-immunoglobulin","name":"B-cell aplasia and low antibodies after CAR-T and bispecifics, and immunoglobulin replacement","tldr":"Treatments aimed at a protein on B cells cannot tell a cancerous B cell from a healthy one, so they remove both, antibody levels fall and infections become more frequent. The fix is to give the antibodies back every few weeks. In one myeloma study, serious infections were ten times less frequent while people were receiving immunoglobulin.","route":"/technologies/rejuv-tx-b-cell-aplasia-and-immunoglobulin/","status":"standard-of-care","kind":"technology","schematic":{"id":"rejuv-tx-b-cell-aplasia-and-immunoglobulin","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"immune","href":"/tagged/immune/","tip":"Every record tagged immune."},{"label":"antibody","href":"/tagged/antibody/","tip":"Every record tagged antibody."}]},"sortKeys":{"year":0}},{"id":"bst-barcelona-cord-blood-bank","name":"Banc de Sang i Teixits cord blood bank, Barcelona","tldr":"The public cord blood bank of Catalonia's Blood and Tissue Bank. It stores more than 20,000 donated cord blood units, and 2,000 have been transplanted in about thirty countries.","route":"/institutions/bst-barcelona-cord-blood-bank/","kind":"institution","avatar":"org","sub":"Barcelona, ES","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-prolonged-cytopenias","name":"Blood counts that do not come back after CAR-T: ICAHT","tldr":"After CAR-T the blood counts often take much longer to recover than after ordinary chemotherapy, and in some people they dip again weeks later after appearing to have recovered. Since 2023 this has had a name, ICAHT, and an agreed grading system, which matters because it means it is measured and reported rather than described loosely.","route":"/technologies/rejuv-tx-prolonged-cytopenias/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-prolonged-cytopenias","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2023"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2023"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"cell-therapy","href":"/tagged/cell-therapy/","tip":"Every record tagged cell-therapy."},{"label":"cytopenias","href":"/tagged/cytopenias/","tip":"Every record tagged cytopenias."}]},"sortKeys":{"year":2023}},{"id":"rejuv-tx-bone-eyes-kidneys-lungs","name":"Bone, eyes, kidneys and lungs after transplant","tldr":"Four problems that turn up years later and are easy to miss because each belongs to a different specialty: bone that thins or, less often, dies at the hip; cataract, which is common after total body irradiation and is fixed by an operation; kidney function that drifts down; and lungs that stiffen rather than obstruct. Each has a cheap test.","route":"/technologies/rejuv-tx-bone-eyes-kidneys-lungs/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-bone-eyes-kidneys-lungs","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"late-effects","href":"/tagged/late-effects/","tip":"Every record tagged late-effects."},{"label":"organ","href":"/tagged/organ/","tip":"Every record tagged organ."}]},"sortKeys":{"year":0}},{"id":"tzu-chi-stem-cells-center","name":"Buddhist Tzu Chi Stem Cells Center (BTCSCC)","tldr":"A volunteer stem cell donor registry in Taiwan, based at Tzu Chi Hospital in Hualien and listed by the World Marrow Donor Association as one of its member registries.","route":"/institutions/tzu-chi-stem-cells-center/","kind":"institution","avatar":"org","sub":"Hualien, TW","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"canadian-blood-services-stem-cell-registry","name":"Canadian Blood Services' Stem Cell Registry","tldr":"Canada's national registry of adult stem cell donors and national public cord blood bank, run by Canadian Blood Services for every province and territory except Quebec.","route":"/institutions/canadian-blood-services-stem-cell-registry/","kind":"institution","avatar":"org","sub":"Ottawa, CA","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"carolinas-cord-blood-bank","name":"Carolinas Cord Blood Bank (Duke)","tldr":"One of the largest public cord blood banks in the world, part of Duke University School of Medicine. Mothers donate their babies' cord blood, and the units are listed on the NMDP registry for unrelated patients.","route":"/institutions/carolinas-cord-blood-bank/","kind":"institution","avatar":"org","sub":"Duke University · Durham, US","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"china-marrow-donor-program","name":"China Marrow Donor Program (CMDP)","tldr":"China's national registry of volunteer blood stem cell donors, known in Chinese as 中华骨髓库.","route":"/institutions/china-marrow-donor-program/","kind":"institution","avatar":"org","sub":"Beijing, CN","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"gvhd-chronic-overview","name":"Chronic graft-versus-host disease","tldr":"After a donor transplant the new immune system can treat the body it has landed in as foreign. When that goes on past the first few months it is called chronic graft-versus-host disease, and it affects roughly four in ten adults. It is treatable and often improves, and the same donor immunity also keeps the leukaemia away, so the aim is to control it rather than abolish it.","route":"/technologies/gvhd-chronic-overview/","status":"established","kind":"technology","schematic":{"id":"gvhd-chronic-overview","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"gvhd","href":"/tagged/gvhd/","tip":"Every record tagged gvhd."},{"label":"immune","href":"/tagged/immune/","tip":"Every record tagged immune."}]},"sortKeys":{"year":0}},{"id":"gvhd-organ-by-organ","name":"Chronic GvHD organ by organ: skin, mouth, eyes, gut, liver, joints and genital tract","tldr":"Chronic GvHD is a pattern of injuries that can appear in several places at once: skin that thickens, a dry sore mouth, dry painful eyes, difficulty swallowing, abnormal liver tests, stiff joints, genital narrowing. Several of the best treatments are local rather than systemic. The eye and genital problems are the ones least often raised.","route":"/technologies/gvhd-organ-by-organ/","status":"established","kind":"technology","schematic":{"id":"gvhd-organ-by-organ","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"gvhd","href":"/tagged/gvhd/","tip":"Every record tagged gvhd."},{"label":"organ","href":"/tagged/organ/","tip":"Every record tagged organ."}]},"sortKeys":{"year":0}},{"id":"datri","name":"DATRI Blood Stem Cell Donors Registry","tldr":"An Indian not-for-profit registry of unrelated blood stem cell donors, founded in 2009 because Indian patients rarely found a matched donor on registries abroad.","route":"/institutions/datri/","kind":"institution","avatar":"org","sub":"Chennai, IN","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"dkms-registry","name":"DKMS Registry","tldr":"The international registry of DKMS, the blood stem cell donor charity that began in Germany. It lists DKMS donors from Germany, the UK, Poland, Chile, India and South Africa so transplant centres anywhere can search and request them.","route":"/institutions/dkms-registry/","kind":"institution","avatar":"org","sub":"Tübingen, DE","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"dkms-uk","name":"DKMS United Kingdom","tldr":"The UK branch of DKMS, a charity that recruits people aged 16 to 55 onto the blood stem cell donor register so that patients with blood cancer who have no family match can find a donor.","route":"/institutions/dkms-uk/","kind":"institution","avatar":"org","sub":"London, GB","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"gvhd-photopheresis","name":"Extracorporeal photopheresis for graft-versus-host disease","tldr":"Blood is taken out through a machine, the white cells are treated with a light-sensitive drug and ultraviolet light, and given back. It is used for GvHD that steroids have not controlled, mainly skin and mouth, and it spares people more immunosuppression. Improvement builds over months, so it means two sessions a week for a long time.","route":"/technologies/gvhd-photopheresis/","status":"established","kind":"technology","schematic":{"id":"gvhd-photopheresis","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2008"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2008"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"gvhd","href":"/tagged/gvhd/","tip":"Every record tagged gvhd."},{"label":"treatment","href":"/tagged/treatment/","tip":"Every record tagged treatment."},{"label":"apheresis","href":"/tagged/apheresis/","tip":"Every record tagged apheresis."}]},"sortKeys":{"year":2008}},{"id":"ezer-mizion-bone-marrow-registry","name":"Ezer Mizion Bone Marrow Donor Registry","tldr":"An Israeli bone marrow donor registry run by the health-support charity Ezer Mizion since 1998. Since 2005 every new soldier in the Israel Defense Forces can join it at induction.","route":"/institutions/ezer-mizion-bone-marrow-registry/","kind":"institution","avatar":"org","sub":"Petah Tikva, IL","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-fertility-and-growth","name":"Fertility, growth and what total body irradiation costs","tldr":"Transplant conditioning, and total body irradiation in particular, usually ends natural fertility and in children slows growth. The decisions that preserve the most are made before conditioning starts. A randomised trial in children with leukaemia tested replacing the radiation with chemotherapy and found the radiation worked better.","route":"/technologies/rejuv-tx-fertility-and-growth/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-fertility-and-growth","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"fertility","href":"/tagged/fertility/","tip":"Every record tagged fertility."},{"label":"late-effects","href":"/tagged/late-effects/","tip":"Every record tagged late-effects."},{"label":"radiation","href":"/tagged/radiation/","tip":"Every record tagged radiation."}]},"sortKeys":{"year":0}},{"id":"france-greffe-de-moelle","name":"France Greffe de Moelle (French stem cell donor registry)","tldr":"France's national register of volunteer bone marrow donors, run by the Agence de la biomédecine, the public agency under the health ministry.","route":"/institutions/france-greffe-de-moelle/","kind":"institution","avatar":"org","sub":"Saint-Denis, FR","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"gift-of-life-marrow-registry","name":"Gift of Life Marrow Registry","tldr":"A US nonprofit blood stem cell and marrow registry that recruits donors by mail-in cheek swab and arranges transplants for patients with leukaemia, lymphoma, sickle cell disease and inherited immune disorders.","route":"/institutions/gift-of-life-marrow-registry/","kind":"institution","avatar":"org","sub":"Boca Raton, US","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"hema-quebec-stem-cell-registry","name":"Héma-Québec Stem Cell Donor Registry","tldr":"Quebec's own register of volunteer stem cell donors, run by Héma-Québec, the province's blood service. People aged 18 to 35 in good health can join.","route":"/institutions/hema-quebec-stem-cell-registry/","kind":"institution","avatar":"org","sub":"Montreal, CA","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"hong-kong-bone-marrow-donor-registry","name":"Hong Kong Bone Marrow Donor Registry","tldr":"Hong Kong's register of volunteer marrow and blood stem cell donors, run by the Hong Kong Red Cross Blood Transfusion Service.","route":"/institutions/hong-kong-bone-marrow-donor-registry/","kind":"institution","avatar":"org","sub":"Hong Kong, HK","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-endocrine-and-cardiometabolic","name":"Hormones, metabolism and the heart after transplant","tldr":"Transplant conditioning can leave the thyroid underactive, the ovaries or testes not working, and the handling of sugar and fat altered in a way that raises heart risk years later. Much of this is treatable with ordinary medicine, and the familiar things about weight, exercise and smoking matter more here than usual, not less.","route":"/technologies/rejuv-tx-endocrine-and-cardiometabolic/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-endocrine-and-cardiometabolic","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"late-effects","href":"/tagged/late-effects/","tip":"Every record tagged late-effects."},{"label":"endocrine","href":"/tagged/endocrine/","tip":"Every record tagged endocrine."},{"label":"heart","href":"/tagged/heart/","tip":"Every record tagged heart."}]},"sortKeys":{"year":0}},{"id":"gvhd-nih-consensus-criteria","name":"How chronic GvHD is diagnosed and scored: the NIH consensus criteria","tldr":"There is an agreed way to say how bad chronic GvHD is, and every trial, drug label and treatment decision uses it. Each affected organ scores 0 to 3, and the pattern gives an overall verdict of mild, moderate or severe. Worth asking: which organs are scored, what each score is, and what the global severity is.","route":"/technologies/gvhd-nih-consensus-criteria/","status":"established","kind":"technology","schematic":{"id":"gvhd-nih-consensus-criteria","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2014"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2014"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"gvhd","href":"/tagged/gvhd/","tip":"Every record tagged gvhd."},{"label":"grading","href":"/tagged/grading/","tip":"Every record tagged grading."}]},"sortKeys":{"year":2014}},{"id":"rejuv-tx-icans-and-neurocognition","name":"ICANS, and whether thinking recovers after CAR-T","tldr":"CAR-T can cause a short-lived brain disturbance in the first weeks: confusion, trouble finding words, tremor, sometimes seizures. It almost always resolves. Afterwards, measured outcomes for most people are close to the general population, while a substantial minority report trouble with memory or concentration.","route":"/technologies/rejuv-tx-icans-and-neurocognition/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-icans-and-neurocognition","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"cell-therapy","href":"/tagged/cell-therapy/","tip":"Every record tagged cell-therapy."},{"label":"cognition","href":"/tagged/cognition/","tip":"Every record tagged cognition."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-infection-by-phase","name":"Infection risk after transplant and cell therapy, phase by phase, and the prophylaxis that follows it","tldr":"Which infections threaten someone after a transplant depends almost entirely on how long it has been, because the immune system returns in a known order: bacteria and fungi first, viruses such as cytomegalovirus in the middle months, encapsulated bacteria later. The preventive medicines are matched to those phases.","route":"/technologies/rejuv-tx-infection-by-phase/","status":"standard-of-care","kind":"technology","schematic":{"id":"rejuv-tx-infection-by-phase","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"immune","href":"/tagged/immune/","tip":"Every record tagged immune."},{"label":"infection","href":"/tagged/infection/","tip":"Every record tagged infection."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-iron-overload","name":"Iron overload after transplant","tldr":"Every unit of red cells carries iron the body cannot excrete, and someone who has been through leukaemia treatment may have had dozens. It settles in the liver and sometimes the heart. A blood test finds it and an MRI confirms it, and it can be removed either by a chelating drug or by taking blood off once the marrow is working again.","route":"/technologies/rejuv-tx-iron-overload/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-iron-overload","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"late-effects","href":"/tagged/late-effects/","tip":"Every record tagged late-effects."},{"label":"iron","href":"/tagged/iron/","tip":"Every record tagged iron."}]},"sortKeys":{"year":0}},{"id":"ibmdr","name":"Italian Bone Marrow Donor Registry (IBMDR)","tldr":"Italy's national registry of unrelated bone marrow donors, founded in 1989 at the Galliera hospitals in Genoa. It searches for donors and cord blood units in Italy and abroad for patients with no family match.","route":"/institutions/ibmdr/","kind":"institution","avatar":"org","sub":"Genoa, IT","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"jmdp","name":"Japan Marrow Donor Program (JMDP)","tldr":"Japan's national bank of unrelated marrow and blood stem cell donors, set up in 1991 under a government initiative with the Japanese Red Cross Society.","route":"/institutions/jmdp/","kind":"institution","avatar":"org","sub":"Tokyo, JP","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"jose-carreras-cord-blood-bank-duesseldorf","name":"José Carreras Cord Blood Bank Düsseldorf","tldr":"A public cord blood bank at Düsseldorf University Hospital, founded in 1992 with the German José Carreras Leukaemia Foundation. Its unrelated-donor cord blood is licensed as a medicine in Germany.","route":"/institutions/jose-carreras-cord-blood-bank-duesseldorf/","kind":"institution","avatar":"org","sub":"Düsseldorf, DE","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"korea-marrow-donor-program","name":"Korea Marrow Donor Program (KMDP)","tldr":"A Korean nonprofit that recruits and matches unrelated blood stem cell donors. It was founded in 1994 and records more than 7,000 transplants arranged.","route":"/institutions/korea-marrow-donor-program/","kind":"institution","avatar":"org","sub":"Seoul, KR","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-late-effects-overview","name":"Late effects after a stem cell transplant","tldr":"There are now around half a million people alive worldwide who have had a blood or marrow transplant. Most of them have at least one lasting health problem from it, and many have several. The list is long and reads heavily, but almost every item on it is either preventable or detectable early, which is the reason to know what is on it rather than to avoid knowing.","route":"/technologies/rejuv-tx-late-effects-overview/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-late-effects-overview","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"late-effects","href":"/tagged/late-effects/","tip":"Every record tagged late-effects."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-gene-modified-follow-up","name":"Long-term follow-up for gene-modified cell products: fifteen years, and why","tldr":"If you were given a treatment in which your own cells were genetically modified, you are expected to be followed up for fifteen years. Not because something is known to go wrong, but because the gene is inserted permanently and the only honest way to find out what happens over a lifetime is to look.","route":"/technologies/rejuv-tx-gene-modified-follow-up/","status":"standard-of-care","kind":"technology","schematic":{"id":"rejuv-tx-gene-modified-follow-up","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2020"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2020"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"cell-therapy","href":"/tagged/cell-therapy/","tip":"Every record tagged cell-therapy."},{"label":"regulation","href":"/tagged/regulation/","tip":"Every record tagged regulation."}]},"sortKeys":{"year":2020}},{"id":"matchis","name":"Matchis Foundation","tldr":"The Dutch stem cell donor registry. People aged 18 to 35 in the Netherlands can sign up online and send three cheek swabs to be tissue-typed.","route":"/institutions/matchis/","kind":"institution","avatar":"org","sub":"Leiden, NL","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"michel-attal","name":"Michel Attal","tldr":"French haematologist whose trials established autologous stem-cell transplantation for myeloma in the 1990s and, in IFM 2009, showed that transplant still adds benefit in the era of lenalidomide, bortezomib and dexamethasone.","route":"/people/michel-attal/","kind":"person","round":true,"avatar":"person","sub":"Haematologist and Director General, IUCT Oncopole, Toulouse · IUCT Oncopole (Institut Universitaire du Cancer de Toulouse)","facets":{"kind":["Person"],"cancers":["Newly diagnosed multiple myeloma, transplant-eligible","Multiple myeloma"],"year":[]},"cols":{"kind":{"facet":"kind","value":"Person","tip":"The clinicians and scientists doing the work: specialisms, bios, papers, and where to find them."},"cancers":[{"label":"Newly diagnosed multiple myeloma, transplant-eligible","href":"/cancers/myeloma-transplant-eligible/","tip":"Fit patients with newly diagnosed myeloma receive four drugs at once, then their own stem cells are collected, they are given high-dose chemotherapy, the cells are returned and they continue on maintenance. Adding the CD38 antibody daratumumab to the three-drug backbone, tested in PERSEUS and CASSIOPEIA, means most patients now reach a state where no myeloma can be detected."},{"label":"Multiple myeloma","href":"/cancers/multiple-myeloma/","tip":"Multiple myeloma is a plasma-cell cancer with more new drug classes than any other: proteasome inhibitors, IMiDs, CD38 antibodies, BCMA CAR-T, bispecifics, and an ADC."}],"tags":[{"label":"myeloma","href":"/tagged/myeloma/","tip":"Every record tagged myeloma."},{"label":"trialist","href":"/tagged/trialist/","tip":"Every record tagged trialist."}]},"sortKeys":{"year":0}},{"id":"nybc-national-cord-blood-program","name":"National Cord Blood Program, New York Blood Center","tldr":"The world's first public cord blood bank, run by New York Blood Center, which marked its 30th anniversary in February 2023. It stopped collecting in 2020 but keeps more than 27,000 frozen cord blood units for transplants and research.","route":"/institutions/nybc-national-cord-blood-program/","kind":"institution","avatar":"org","sub":"Rye, US","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"nhs-stem-cell-donor-registry","name":"NHS Stem Cell Donor Registry","tldr":"The stem cell donor register run by NHS Blood and Transplant, which blood donors in England can join at a donation appointment. With Anthony Nolan it gives UK transplant centres a single place to search for donors.","route":"/institutions/nhs-stem-cell-donor-registry/","kind":"institution","avatar":"org","sub":"Bristol, GB","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"nmdp","name":"NMDP","tldr":"The United States registry of volunteer stem cell and marrow donors, formerly called the National Marrow Donor Program and Be The Match. It finds unrelated donors and cord blood for patients with blood cancers and other blood disorders, in the US and abroad.","route":"/institutions/nmdp/","kind":"institution","avatar":"org","sub":"Minneapolis, US","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"pieter-sonneveld","name":"Pieter Sonneveld","tldr":"Led PERSEUS, which established daratumumab-VRd as the standard for transplant-eligible myeloma.","route":"/people/pieter-sonneveld/","kind":"person","round":true,"avatar":"person","sub":"Professor of Hematology, Erasmus MC Cancer Institute; Chair, European Myeloma Network · Erasmus MC Cancer Institute","facets":{"kind":["Person"],"cancers":["Multiple myeloma"],"year":[]},"cols":{"kind":{"facet":"kind","value":"Person","tip":"The clinicians and scientists doing the work: specialisms, bios, papers, and where to find them."},"cancers":[{"label":"Multiple myeloma","href":"/cancers/multiple-myeloma/","tip":"Multiple myeloma is a plasma-cell cancer with more new drug classes than any other: proteasome inhibitors, IMiDs, CD38 antibodies, BCMA CAR-T, bispecifics, and an ADC."}],"tags":[{"label":"myeloma","href":"/tagged/myeloma/","tip":"Every record tagged myeloma."},{"label":"hovon","href":"/tagged/hovon/","tip":"Every record tagged hovon."}]},"sortKeys":{"year":0}},{"id":"gvhd-prophylaxis","name":"Preventing graft-versus-host disease, and what prevention costs","tldr":"Every donor transplant includes drugs to stop the new immune system attacking the body. A randomised trial in 2023 changed the usual choice: cyclophosphamide after the transplant, with tacrolimus and mycophenolate, worked better than the older combination. Prevention is not free, because the same drugs hold back the response to infection.","route":"/technologies/gvhd-prophylaxis/","status":"standard-of-care","kind":"technology","schematic":{"id":"gvhd-prophylaxis","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2023"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2023"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"gvhd","href":"/tagged/gvhd/","tip":"Every record tagged gvhd."},{"label":"prevention","href":"/tagged/prevention/","tip":"Every record tagged prevention."}]},"sortKeys":{"year":2023}},{"id":"rejuv-tx-quality-of-life","name":"Quality of life after transplant and cell therapy","tldr":"Most people who come through a transplant or CAR-T report, years later, a quality of life close to that of people who never had one. Underneath that, a substantial minority live with fatigue, anxiety, low mood or trouble concentrating, and the strongest predictor is having had anxiety or depression before treatment, which is treatable.","route":"/technologies/rejuv-tx-quality-of-life/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-quality-of-life","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"quality-of-life","href":"/tagged/quality-of-life/","tip":"Every record tagged quality-of-life."},{"label":"psychosocial","href":"/tagged/psychosocial/","tip":"Every record tagged psychosocial."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-immune-reconstitution-timeline","name":"Rebuilding an immune system: the timeline, lineage by lineage","tldr":"After a transplant the immune system comes back in a fixed order, and the order explains most of what follows. Neutrophils in two to four weeks, natural killer cells within a month, B cells over several months to a year, and T cells last and slowest. Adults rebuild a narrower repertoire, because the thymus shrinks with age.","route":"/technologies/rejuv-tx-immune-reconstitution-timeline/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-immune-reconstitution-timeline","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"immune","href":"/tagged/immune/","tip":"Every record tagged immune."},{"label":"reconstitution","href":"/tagged/reconstitution/","tip":"Every record tagged reconstitution."}]},"sortKeys":{"year":0}},{"id":"redmo","name":"REDMO (Spanish Bone Marrow Donors Registry)","tldr":"Spain's register of bone marrow donors, run by the Josep Carreras Leukaemia Foundation in Barcelona.","route":"/institutions/redmo/","kind":"institution","avatar":"org","sub":"Barcelona, ES","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"redome","name":"REDOME (Brazilian Registry of Voluntary Bone Marrow Donors)","tldr":"Brazil's national register of volunteer bone marrow donors, run by the National Cancer Institute (INCA) in Rio de Janeiro. It describes itself as the third-largest bone marrow donor bank in the world.","route":"/institutions/redome/","kind":"institution","avatar":"org","sub":"Rio de Janeiro, BR","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-revaccination","name":"Revaccination after transplant: the schedules, and where the UK and the US differ","tldr":"A transplant erases the protection built up by a lifetime of vaccinations, including childhood ones, and it has to be rebuilt. Published schedules exist, the vaccines are free at the point of use in the NHS, and the usual failure is that nobody writes the plan down. If you have had a transplant and have no written schedule, ask for one.","route":"/technologies/rejuv-tx-revaccination/","status":"standard-of-care","kind":"technology","schematic":{"id":"rejuv-tx-revaccination","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2019"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2019"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"immune","href":"/tagged/immune/","tip":"Every record tagged immune."},{"label":"vaccination","href":"/tagged/vaccination/","tip":"Every record tagged vaccination."}]},"sortKeys":{"year":2019}},{"id":"saudi-stem-cells-donor-registry","name":"Saudi Stem Cells Donor Registry (SSCDR)","tldr":"Saudi Arabia's volunteer stem cell donor registry, based at the King Abdullah International Medical Research Center in Riyadh.","route":"/institutions/saudi-stem-cells-donor-registry/","kind":"institution","avatar":"org","sub":"Riyadh, SA","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-second-cancers","name":"Second cancers after allogeneic transplant","tldr":"People who have had a donor transplant develop new, unrelated cancers about twice as often as people of the same age, and by fifteen years about three times as often. Radiation in the conditioning matters most for those irradiated young, and chronic GvHD raises squamous cancers of skin and mouth. Both point at lifelong screening.","route":"/technologies/rejuv-tx-second-cancers/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-second-cancers","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"late-effects","href":"/tagged/late-effects/","tip":"Every record tagged late-effects."},{"label":"second-cancer","href":"/tagged/second-cancer/","tip":"Every record tagged second-cancer."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-secondary-t-cell-malignancy","name":"Secondary T-cell malignancy after CAR-T, and what the FDA's 2024 action actually says","tldr":"In 2024 the US regulator added a warning to every approved CAR-T product about T-cell cancers after treatment. It says the risk applies to the class, that these can appear within weeks, and that patients should be monitored for life. It does not say CAR-T causes most of them, and published series find them very rare.","route":"/technologies/rejuv-tx-secondary-t-cell-malignancy/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-secondary-t-cell-malignancy","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2024"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2024"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"cell-therapy","href":"/tagged/cell-therapy/","tip":"Every record tagged cell-therapy."},{"label":"second-cancer","href":"/tagged/second-cancer/","tip":"Every record tagged second-cancer."}]},"sortKeys":{"year":2024}},{"id":"sabmr","name":"South African Bone Marrow Registry (SABMR)","tldr":"South Africa's national bone marrow donor registry, started in Cape Town in 1991. It finds unrelated donors locally and through registries abroad for the roughly 70 per cent of patients with no family match.","route":"/institutions/sabmr/","kind":"institution","avatar":"org","sub":"Cape Town, ZA","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"stem-cell-donors-australia","name":"Stem Cell Donors Australia","tldr":"Australia's national blood stem cell donor registry, formerly called Strength to Give and the ABMDR. It recruits donors and links Australian patients with donors overseas, and overseas patients with Australian donors.","route":"/institutions/stem-cell-donors-australia/","kind":"institution","avatar":"org","sub":"Sydney, AU","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"rejuv-tx-survival-after-transplant","name":"Survival after transplant, and why the curve never quite rejoins the population","tldr":"If you are alive and free of disease two years after a donor transplant, around nine in ten are alive five years later and 85 per cent at ten years. The death rate among transplant survivors stays higher than in people of the same age who never had one, for many years. The two things that matter most are age and chronic graft-versus-host disease.","route":"/technologies/rejuv-tx-survival-after-transplant/","status":"established","kind":"technology","schematic":{"id":"rejuv-tx-survival-after-transplant","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"late-effects","href":"/tagged/late-effects/","tip":"Every record tagged late-effects."},{"label":"survival","href":"/tagged/survival/","tip":"Every record tagged survival."}]},"sortKeys":{"year":0}},{"id":"thai-national-stem-cell-donor-registry","name":"Thai National Stem Cell Donor Registry","tldr":"Thailand's national register of volunteer blood stem cell donors, run by the National Blood Centre of the Thai Red Cross Society in Bangkok.","route":"/institutions/thai-national-stem-cell-donor-registry/","kind":"institution","avatar":"org","sub":"Bangkok, TH","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"gvhd-lung-bronchiolitis-obliterans","name":"The lungs after transplant: bronchiolitis obliterans syndrome","tldr":"The smallest airways in the lung can scar shut after a donor transplant. It is the form of chronic GvHD that changes the outlook most, and it is usually silent until a lot of lung function has gone. It is found by breathing tests on a schedule rather than by waiting for breathlessness, so asking for spirometry is worth doing.","route":"/technologies/gvhd-lung-bronchiolitis-obliterans/","status":"established","kind":"technology","schematic":{"id":"gvhd-lung-bronchiolitis-obliterans","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"gvhd","href":"/tagged/gvhd/","tip":"Every record tagged gvhd."},{"label":"lung","href":"/tagged/lung/","tip":"Every record tagged lung."}]},"sortKeys":{"year":0}},{"id":"welsh-bone-marrow-donor-registry","name":"Welsh Bone Marrow Donor Registry (WBMDR)","tldr":"The stem cell donor register run by the Welsh Blood Service. People can join from 16 until their 31st birthday, or until their 46th if they are of Black, Asian, mixed heritage or minority ethnic background.","route":"/institutions/welsh-bone-marrow-donor-registry/","kind":"institution","avatar":"org","sub":"Pontyclun, GB","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"gvhd-ruxolitinib-steroid-refractory","name":"When steroids fail: ruxolitinib for steroid-refractory GvHD","tldr":"First treatment for graft-versus-host disease is steroids, and in about half of people with chronic disease they do not work or cannot be reduced. Ruxolitinib is the only drug that has beaten the alternatives in a randomised trial here, and it has done so twice. About half of people respond; the common problems are low platelets and low haemoglobin.","route":"/technologies/gvhd-ruxolitinib-steroid-refractory/","status":"approved","kind":"technology","schematic":{"id":"gvhd-ruxolitinib-steroid-refractory","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2019"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2019"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"gvhd","href":"/tagged/gvhd/","tip":"Every record tagged gvhd."},{"label":"treatment","href":"/tagged/treatment/","tip":"Every record tagged treatment."}]},"sortKeys":{"year":2019}},{"id":"rejuv-tx-long-term-follow-up-frameworks","name":"Who is supposed to be watching: EBMT, CIBMTR, FACT-JACIE, and what a survivor is actually offered","tldr":"There is an agreed international list of what should be checked in someone who has had a transplant, and how often, and an accreditation system that centres are inspected against. What there is much less of is a guarantee that any individual survivor is receiving the checks. Knowing the list exists lets a person ask for it.","route":"/technologies/rejuv-tx-long-term-follow-up-frameworks/","status":"standard-of-care","kind":"technology","schematic":{"id":"rejuv-tx-long-term-follow-up-frameworks","sections":["rejuvenation","supportive-care"]},"facets":{"kind":["Technology"],"cancers":[],"year":["2012"]},"cols":{"kind":{"facet":"kind","value":"Technology","tip":"Every way we see, measure, or attack a tumour, explained."},"cancers":[],"year":{"facet":"year","value":"2012"},"tags":[{"label":"rejuvenation","href":"/tagged/rejuvenation/","tip":"Every record tagged rejuvenation."},{"label":"survivorship","href":"/tagged/survivorship/","tip":"Every record tagged survivorship."},{"label":"follow-up","href":"/tagged/follow-up/","tip":"Every record tagged follow-up."},{"label":"standards","href":"/tagged/standards/","tip":"Every record tagged standards."}]},"sortKeys":{"year":2012}},{"id":"wmda","name":"World Marrow Donor Association (WMDA)","tldr":"The international association of stem cell donor registries and cord blood banks. When a patient needs a stem cell transplant and nobody in the family matches, transplant doctors search the donors of every member registry at once through WMDA's database.","route":"/institutions/wmda/","kind":"institution","avatar":"org","sub":"Leiden, NL","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}},{"id":"zkrd","name":"ZKRD: German National Bone Marrow Donor Registry","tldr":"Germany's central office for finding unrelated stem cell donors. It holds the data of donors from 26 German donor centres and searches registries worldwide; the ZKRD says almost 40 per cent of unrelated stem cell transplants worldwide use donors from Germany.","route":"/institutions/zkrd/","kind":"institution","avatar":"org","sub":"Ulm, DE","facets":{"kind":["Institution"],"cancers":[],"year":[]},"cols":{"kind":{"facet":"kind","value":"Institution","tip":"The centres and universities that matter, mapped and ranked."},"cancers":[],"tags":[{"label":"stem-cell","href":"/tagged/stem-cell/","tip":"Every record tagged stem-cell."}]},"sortKeys":{"year":0}}]