{"slug":"car-t-target","tag":"car-t-target","variants":["car-t-target"],"description":"No description yet","count":8,"kinds":{"target":8},"related":[{"slug":"adc-target","tag":"adc-target","shared":3},{"slug":"antibody-target","tag":"antibody-target","shared":1},{"slug":"t-cell-engager-target","tag":"t-cell-engager-target","shared":1}],"records":[{"id":"cd22","kind":"target","name":"CD22","route":"/targets/cd22/","tldr":"CD22 is a B-cell surface protein and the docking site for the leukaemia ADC inotuzumab ozogamicin."},{"id":"gd2","kind":"target","name":"GD2 (disialoganglioside)","route":"/targets/gd2/","tldr":"GD2 is a sugar-fat molecule on the surface of neuroblastoma cells (and some other childhood and adult tumours) with almost none on normal tissue except nerves, which is why anti-GD2 drugs cause pain."},{"id":"cldn18-2","kind":"target","name":"Claudin 18.2","route":"/targets/cldn18-2/","tldr":"A tight-junction protein normally hidden in the stomach lining that becomes exposed in gastric and pancreatic cancers."},{"id":"gpc3","kind":"target","name":"Glypican-3","route":"/targets/gpc3/","tldr":"Glypican-3 is a fetal liver protein that reappears in liver cancer, giving CAR-T and bispecifics a clean target."},{"id":"mesothelin","kind":"target","name":"Mesothelin","route":"/targets/mesothelin/","tldr":"Mesothelin is a surface protein on mesothelioma, ovarian, and pancreatic cancers, targeted by ADCs, CAR-T, and T-cell engagers."},{"id":"cd70","kind":"target","name":"CD70","route":"/targets/cd70/","tldr":"CD70 is a protein normally only on activated immune cells, but permanently switched on in kidney cancer and some leukaemias."},{"id":"cd19","kind":"target","name":"CD19","route":"/targets/cd19/","tldr":"CD19 is a marker on B cells and B-cell cancers, and was the target of the first CAR-T therapies ever approved."},{"id":"bcma","kind":"target","name":"BCMA","route":"/targets/bcma/","tldr":"BCMA is a survival receptor on plasma cells, and the target that made CAR-T and bispecifics work in multiple myeloma."}]}