{"slug":"cell-therapy","tag":"cell-therapy","variants":["cell-therapy"],"description":"No description yet","count":11,"kinds":{"person":11},"related":[{"slug":"car-t","tag":"car-t","shared":7},{"slug":"lymphoma","tag":"lymphoma","shared":3},{"slug":"paediatric","tag":"paediatric","shared":3},{"slug":"engineering","tag":"engineering","shared":1},{"slug":"gene-editing","tag":"gene-editing","shared":1},{"slug":"melanoma","tag":"melanoma","shared":1},{"slug":"nk-cells","tag":"nk-cells","shared":1},{"slug":"off-the-shelf","tag":"off-the-shelf","shared":1},{"slug":"sarcoma","tag":"sarcoma","shared":1},{"slug":"solid-tumours","tag":"solid-tumours","shared":1},{"slug":"tcr-t","tag":"tcr-t","shared":1},{"slug":"til","tag":"til","shared":1}],"records":[{"id":"sandra-dangelo","kind":"person","name":"Sandra P. D'Angelo","route":"/people/sandra-dangelo/","tldr":"Led SPEARHEAD-1, the trial that made afami-cel the first engineered TCR T-cell therapy approved for a solid tumour."},{"id":"sattva-neelapu","kind":"person","name":"Sattva S. Neelapu","route":"/people/sattva-neelapu/","tldr":"Led ZUMA-1, the trial that made axicabtagene ciloleucel the first CAR-T therapy approved for lymphoma."},{"id":"stephen-schuster","kind":"person","name":"Stephen J. Schuster","route":"/people/stephen-schuster/","tldr":"Led JULIET, which brought tisagenlecleucel, the first CAR-T, to adults with relapsed large B-cell lymphoma."},{"id":"michel-sadelain","kind":"person","name":"Michel Sadelain","route":"/people/michel-sadelain/","tldr":"Designed the second-generation CAR with a CD28 costimulatory domain that made CAR-T therapy work."},{"id":"stephan-grupp","kind":"person","name":"Stephan A. Grupp","route":"/people/stephan-grupp/","tldr":"Treated the first child with CAR-T cells and led ELIANA, the trial behind the first CAR-T approval."},{"id":"marcela-maus","kind":"person","name":"Marcela V. Maus","route":"/people/marcela-maus/","tldr":"Cell therapy engineer whose CAR-TEAM cells produced rapid regressions of recurrent glioblastoma."},{"id":"waseem-qasim","kind":"person","name":"Waseem Qasim","route":"/people/waseem-qasim/","tldr":"Delivered the first gene-edited off-the-shelf CAR-T cells to infants with leukaemia and the first base-edited CAR-T therapy."},{"id":"katy-rezvani","kind":"person","name":"Katayoun Rezvani","route":"/people/katy-rezvani/","tldr":"Created cord blood-derived CAR-NK cells, the first off-the-shelf CAR cell therapy to show remissions in lymphoma."},{"id":"inge-marie-svane","kind":"person","name":"Inge Marie Svane","route":"/people/inge-marie-svane/","tldr":"Led the Dutch-Danish trial that proved TIL therapy beats ipilimumab in melanoma, the first randomised win for a cell therapy in a solid tumour."},{"id":"robbie-majzner","kind":"person","name":"Robbie G. Majzner","route":"/people/robbie-majzner/","tldr":"Led the GD2 CAR-T trial in diffuse midline glioma and defined antigen density as a barrier to CAR-T in solid tumours."},{"id":"caron-jacobson","kind":"person","name":"Caron A. Jacobson","route":"/people/caron-jacobson/","tldr":"Boston lymphoma doctor who led ZUMA-5, the trial that brought the CAR-T therapy axicabtagene ciloleucel to relapsed follicular lymphoma."}]}