{"slug":"diarrhoea","tag":"diarrhoea","variants":["diarrhoea"],"description":"No description yet","count":3,"kinds":{"protocol":3},"related":[{"slug":"protocol","tag":"protocol","shared":3},{"slug":"supportive-care","tag":"supportive-care","shared":3}],"records":[{"id":"irinotecan-early-cholinergic-syndrome-and-late-diarrhoea","kind":"protocol","name":"Irinotecan: early cholinergic syndrome and late diarrhoea","route":"/protocols/irinotecan-early-cholinergic-syndrome-and-late-diarrhoea/","tldr":"Irinotecan can cause two kinds of diarrhoea. The first comes during or soon after the drip, with sweating, watery eyes and cramps; an atropine injection stops it. The second starts a day or more later and can be serious: take 4 mg of loperamide at the first loose stool, then 2 mg every 2 hours, and call your team if it is not controlled in 24 hours, or with blood, fever or faintness."},{"id":"neratinib-diarrhoea-prophylaxis-and-dose-escalation","kind":"protocol","name":"Neratinib: diarrhoea prevention with loperamide or dose escalation","route":"/protocols/neratinib-diarrhoea-prophylaxis-and-dose-escalation/","tldr":"Neratinib, a tablet for HER2-positive breast cancer, causes diarrhoea in almost everyone. Prevent it in one of two ways agreed before you start: loperamide on a fixed schedule from the first tablet for eight weeks, or a lower starting dose built up over two weeks. Drink about two litres a day, and call your team at once if diarrhoea is severe or comes with weakness, dizziness or fever."},{"id":"treatment-induced-diarrhoea-grading-and-management","kind":"protocol","name":"Diarrhoea from chemotherapy, targeted therapy and radiotherapy: grading, loperamide, octreotide and when to admit","route":"/protocols/treatment-induced-diarrhoea-grading-and-management/","tldr":"Treatment diarrhoea can turn dangerous quickly, especially with a low blood count. Drink plenty and start loperamide at the first loose stool if your team has told you to. Call the 24-hour line at once if it does not settle within a day, if there are seven or more stools a day, or with fever, blood, vomiting or dizziness. If cancer tablets are the cause and loperamide fails, stop them and ring."}]}